ZFIN ID: ZDB-GENE-990621-3
Gene Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Symbol: dbh
Sequence Ontology ID : SO:0000704

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 36 figures from 23 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Adult (90d-730d, breeding adult)
  adrenergic neuron, brain, chromaffin cell, cranial ganglion (all 24) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct806 Insertion Exon 3 Premature Stop ZINC_FINGER_NUCLEASE
sa21676 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24865 Point Mutation Unknown Splice Site ENU
    PHENOTYPE
    Data: 2 figures from Singh et al., 2015
    Observed in: locomotory behavior, sleep
    DISEASE ASSOCIATED WITH dbh HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dopamine beta-hydroxylase deficiency Dopamine beta-hydroxylase deficiency 223360
    [Dopamine-beta-hydroxylase activity levels, plasma]
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sleep (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000323
  • InterPro:IPR000945
  • InterPro:IPR005018
  • InterPro:IPR008977
  • InterPro:IPR014783
  • InterPro:IPR014784
  • InterPro:IPR024548
  • InterPro:IPR028460
  • PROSITE:PS00085
  • PROSITE:PS50836
  • Pfam:PF01082
  • Pfam:PF03351
  • Pfam:PF03712
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dbh-001 (1) 1953
    ncRNA dbh-002 (1) 858
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM dbh
    Tg(dbh:EGFP), Tg(dbh:EGFP-Hsa.MYCN), Tg(dbh:GAL4FF), Tg(dbh:Hsa.ALK_F1174L), tg(dbh:hsa.diexf) (all 15) expand
    MARKER RELATIONSHIPS
    dbhContained in: [BAC] CH211-270H11 (1) (order this)
    dbhEncodes: [cDNA] MGC:194632 (1) (order this), MGC:194650 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001109694 (1) 1953bp
    Genomic GenBank:AL935290 (1) 129665bp
    Select Tool
    Polypeptide UniProtKB:B3DGL8 614aa
    Sequence Clusters UniGene:21021 (1)
    Sequence Information (all 16)
    OTHER dbh GENE PAGES
  • Gene:30505 (1)
  • VEGA:OTTDARG00000019526 (1)
  • Ensembl(GRCz10):ENSDARG00000069446 (1)
  • ORTHOLOGY for dbh (Chr: 10)
    CITATIONS (55)