Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990621-3
Gene Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Symbol: dbh
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 31 figures from 18 publications
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult)
  adrenergic neuron, chromaffin cell, hindbrain, interrenal gland chromaffin cell (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: ct806, sa21676
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Dopamine beta-hydroxylase deficiency 223360
[Dopamine-beta-hydroxylase activity levels, plasma]
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Molecular Function catalytic activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000323 (1)
  • InterPro:IPR000945 (1)
  • InterPro:IPR005018 (1)
  • InterPro:IPR008977 (1)
  • InterPro:IPR014783 (1)
  • InterPro:IPR014784 (1)
  • InterPro:IPR028460 (1)
  • PROSITE:PS00085 (1)
  • PROSITE:PS50836 (1)
  • Pfam:PF01082 (1)
  • Pfam:PF03351 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dbh-001 (1) 1953
    ncRNA dbh-002 (1) 858
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dbh
    Tg(dbh:EGFP), Tg(dbh:EGFP-Hsa.MYCN), Tg(dbh:Hsa.ALK_F1174L)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dbh Contained in: [BAC] CH211-270H11 (1) (order this)
    dbh Encodes: [cDNA] MGC:194632 (1) (order this), MGC:194650 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001109694 (1) 1953 bp
    Genomic GenBank:AL935290 (1) 129665 bp
    Select Tool
    Polypeptide UniProtKB:B3DGL8 (1) 614 aa
    Sequence Clusters UniGene:21021 (1)
    Sequence Information (all 17)
    OTHER dbh GENE PAGES
  • Gene:30505 (1)
  • VEGA:OTTDARG00000019526 (1)
  • Ensembl(Zv9):ENSDARG00000069446 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dbh 10  
    Human DBH 9 (9q34)
  • OMIM:609312
  • Gene:1621
  • Mouse Dbh 2 ( 19.29 cM)
  • MGI:94864
  • Gene:13166
  • Orthology Details
    CITATIONS (39)