Gene

dbh

ID
ZDB-GENE-990621-3
Name
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Symbol
dbh Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have copper ion binding activity and dopamine beta-monooxygenase activity. Involved in sleep. Predicted to localize to extracellular space and secretory granule membrane. Is expressed in endocrine system; head; interrenal primordium; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase).
Genome Resources
Note
None
Expression
All Expression Data
44 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Singh et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dbh Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dopamine beta-hydroxylase deficiency Alliance Orthostatic hypotension 1, due to DBH deficiency 223360
Associated With dbh Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
Domain IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
Domain IPR005018 DOMON domain
Domain IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
Family IPR028460 Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
Homologous_superfamily IPR008977 PHM/PNGase F domain superfamily
Homologous_superfamily IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Homologous_superfamily IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Copper type II ascorbate-dependent monooxygenase, C-terminal Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site Copper type II, ascorbate-dependent monooxygenase-like, C-terminal Copper type II, ascorbate-dependent monooxygenase, N-terminal Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily DOMON domain PHM/PNGase F domain superfamily Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
UniProtKB:Q9W7K6 221
UniProtKB:B3DGL8 614
UniProtKB:A0A2R8QLP9 614
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations