ZFIN ID: ZDB-GENE-990621-3
Gene Name: dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Symbol: dbh
Location: Chr: 10 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 35 figures from 22 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  adrenergic neuron, brain, chromaffin cell, cranial ganglion (all 23) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
ct806 Insertion ZINC_FINGER_NUCLEASE
sa21676 Point Mutation ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dbh HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
[Dopamine-beta-hydroxylase activity levels, plasma]
Dopamine beta-hydroxylase deficiency 223360
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component integral component of membrane (more)
Molecular Function catalytic activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000323 (1)
  • InterPro:IPR000945 (1)
  • InterPro:IPR005018 (1)
  • InterPro:IPR008977 (1)
  • InterPro:IPR014783 (1)
  • InterPro:IPR014784 (1)
  • InterPro:IPR024548 (1)
  • InterPro:IPR028460 (1)
  • PROSITE:PS00085 (1)
  • PROSITE:PS50836 (1)
  • Pfam:PF01082 (1)
  • Pfam:PF03351 (1)
  • Pfam:PF03712 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dbh-001 (1) 1953
    ncRNA dbh-002 (1) 858
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dbh
    Tg(dbh:EGFP), Tg(dbh:EGFP-Hsa.MYCN), Tg(dbh:GAL4FF), Tg(dbh:Hsa.ALK_F1174L), Tg2(dbh:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dbhContained in: [BAC] CH211-270H11 (1) (order this)
    dbhEncodes: [cDNA] MGC:194632 (1) (order this), MGC:194650 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001109694 (1) 1953bp
    Genomic GenBank:AL935290 (1) 129665bp
    Select Tool
    Polypeptide UniProtKB:B3DGL8 (1) 614aa
    Sequence Clusters UniGene:21021 (1)
    Sequence Information (all 17)
    OTHER dbh GENE PAGES
  • Gene:30505 (1)
  • VEGA:OTTDARG00000019526 (1)
  • Ensembl(GRCz10):ENSDARG00000069446 (1)
  • ORTHOLOGY for dbh (Chr: 10)
    Species Symbol Chromosome Accession # Evidence
    Human DBH 9
  • Gene:1621
  • OMIM:609312
  • HGNC:2689
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Dbh 2
  • MGI:94864
  • Gene:13166
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (47)