Gene

her5

ID
ZDB-GENE-990415-90
Name
hairy-related 5
Symbol
her5 Nomenclature History
Previous Names
  • zgc:136537
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including endoderm development; nervous system development; and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Is expressed in several structures, including EVL; brain; endoderm; neural plate; and presumptive structure. Orthologous to human HES7 (hes family bHLH transcription factor 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
46 figures from 33 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Shin et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With her5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 4, autosomal recessive 613686
Associated With her5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003650 Orange domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Orange domain
UniProtKB:F1QJS9 214
UniProtKB:Q504H7 225
UniProtKB:Q1RM23 205
UniProtKB:Q90467 205
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations