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Gene

tle3a

ID
ZDB-GENE-990415-86
Name
TLE family member 3, transcriptional corepressor a
Symbol
tle3a Nomenclature History
Previous Names
  • gro2
  • sb:eu295
  • sb:eu753
  • zfgro2
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable transcription corepressor activity. Acts upstream of or within regulation of retinoic acid biosynthetic process and sclerotome development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; central nervous system; cranial ganglion; mesoderm; and neural rod. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tle3a Human Ortholog
No data available
Associated With tle3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR005617 Groucho/TLE, N-terminal Q-rich domain
Domain IPR017986 WD40-repeat-containing domain
Family IPR009146 Groucho/transducin-like enhancer
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length Groucho/TLE, N-terminal Q-rich domain Groucho/transducin-like enhancer WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q1LXH1 776
UniProtKB:A0A2R8QCK3 778
UniProtKB:O13166 761
UniProtKB:F6NQT3 771
UniProtKB:B3DGV3 762
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations