ZFIN ID: ZDB-GENE-990415-86
Gene Name: TLE family member 3, transcriptional corepressor a
Gene Symbol: tle3a    Nomenclature History

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Previous Names: gro2, sb:eu295, sb:eu753, zfgro2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Involved in regulation of retinoic acid biosynthetic process and sclerotome development. Predicted to localize to nucleus and transcription factor complex. Is expressed in several structures, including axis; central nervous system; cranial ganglion; mesoderm; and neural rod. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor).
Genome Resources: Alliance (1),  Gene:30206 (1),  Ensembl(GRCz11):ENSDARG00000002787 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a349 Insertion Unknown Unknown CRISPR
ihb355 Small Deletion Unknown Unknown CRISPR
ihb356 Insertion Unknown Unknown CRISPR
la020316Tg Transgenic Insertion Unknown Unknown DNA
sa9860 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9885 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14607 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16926 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18545 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23286 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tle3a 1
    CRISPR2-tle3a 1
    CRISPR3-tle3a 1
    CRISPR4-tle3a 1
    CRISPR5-tle3a 1
    MO1-tle3a N/A 1
    MO2-tle3a N/A 1
    MO3-tle3a N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH tle3a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tle3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of retinoic acid biosynthetic process (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tle3a-201 (1)    Ensembl 4151
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tle3a No data available
    MARKER RELATIONSHIPS
    tle3a Contained in: [BAC] CH211-127F10 (1)
    tle3a Encodes: [EST] eu295 (1), eu753 (1), eu874 (1)
    [cDNA] MGC:193724 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131012 (1) 2355 nt
    Genomic GenBank:BX324138 (1) 173169 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QCK3 (1) 778 aa
    Sequence Information (all 36)
    ORTHOLOGY for tle3a ( Chr: 18 )
    CITATIONS (41)