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ZIRC
ZFIN ID: ZDB-GENE-990415-75
Gene Name: notochord homeobox
Gene Symbol: noto    Nomenclature History

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Previous Names: Znot, flh, floating head

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including animal organ development; axial mesoderm morphogenesis; and floor plate formation. Predicted to localize to the nucleus. Is expressed in several structures, including anterior neural keel; forebrain; germ ring; mesoderm; and tail bud. Orthologous to human NOTO (notochord homeobox).
Genome Resources: Alliance (1),  Gene:30260 (1),  Ensembl(GRCz11):ENSDARG00000021201 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la620 Unknown Unknown Unknown ENU
la018405Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m614 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • n1 Small Deletion Unknown Frameshift SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • noto_unspecified Unspecified Unknown Unknown
    sa42164 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tk241 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm229 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-noto N/A 2
    MO2-noto N/A 1
    MO3-noto N/A 2
    PHENOTYPE
    Data: 51 figures from 30 publications
    Observed in:
    DISEASE ASSOCIATED WITH noto HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH noto VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axial mesoderm morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 32)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA noto-201 (1)    Ensembl 991
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM noto
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.6flh:GAP-EGFP) noto EGFP Danio rerio 1 12
    Tg(flh:EGFP) noto EGFP Danio rerio 2 13
    TgBAC(flh:flh-Kaede) noto Kaedenoto Danio rerio 1 7
    MARKER RELATIONSHIPS
    noto Contained in: [BAC] DKEY-159C24 (1) (order this)
    noto Encodes: [cDNA] MGC:193971 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131055 (1) 953 bp
    Genomic GenBank:BX571943 (1) 193538 bp
    Select Tool
    Polypeptide UniProtKB:B8A5N9 (1) 241 aa
    Sequence Clusters UniGene:352 (1)
    Sequence Information (all 14)
    ORTHOLOGY for noto ( Chr: 13 )
    CITATIONS (272)