Gene

fbln1

ID
ZDB-GENE-990415-73
Name
fibulin 1
Symbol
fbln1 Nomenclature History
Previous Names
  • fbln1c (1)
  • fbln1d (1)
  • wu:fc52c06
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and peptidase activator activity. Involved in several processes, including embryonic medial fin morphogenesis; mesenchymal cell migration; and skin morphogenesis. Predicted to localize to extracellular region. Is expressed in several structures, including atrioventricular canal; caudal fin; median fin fold; mesoderm; and tail bud. Orthologous to human FBLN1 (fibulin 1).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fbln1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
synpolydactyly Alliance Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses 608180
Associated With fbln1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000020 Anaphylatoxin/fibulin
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR026823 Complement Clr-like EGF domain
Family IPR017048 Fibulin-1
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Anaphylatoxin/fibulin Complement Clr-like EGF domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Fibulin-1 Growth factor receptor cysteine-rich domain superfamily
UniProtKB:A0A0R4IKI0 679
UniProtKB:B3DH18 681
UniProtKB:A0A0R4ILN6 496
UniProtKB:O42182 681
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations