ZFIN ID: ZDB-GENE-990415-55
Gene Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Gene Symbol: tie1
Sequence Ontology ID : SO:0000704

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Previous Names: tie-1, sb:eu718

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have transmembrane receptor protein tyrosine kinase activity; involved in blood vessel development, endothelial cell-cell adhesion, and heart development; predicted to localize to the  ...
GENE EXPRESSION
All Expression Data: 48 figures from 34 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2005 [eu718]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 2 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH tie1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tie1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR036179 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tie1-201 (1) 4348
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tie1 No data available
    MARKER RELATIONSHIPS
    tie1Contained in: [BAC] CH73-185C24 (1) (order this), CH211-286N19 (1) (order this)
    tie1Encodes: [EST] eu718 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:GU166385 (1) 809bp
    Genomic GenBank:CR936976 154888bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q2A9 (1) 1150aa
    Sequence Information (all 11)
    OTHER tie1 GENE PAGES
  • Alliance (1)
  • VEGA:OTTDARG00000033988 (1)
  • Ensembl(GRCz11):ENSDARG00000004105 (2)
  • ORTHOLOGY for tie1 (Chr: 6)
    CITATIONS (83)