ZFIN ID: ZDB-GENE-990415-55
Gene Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Gene Symbol: tie1    Nomenclature History

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Previous Names: tie-1, sb:eu718

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in blood vessel development; endothelial cell-cell adhesion; and heart development. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; pharyngeal arch; and ventral mesoderm. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
Genome Resources: Alliance (1),  Gene:30746 (1),  Ensembl(GRCz11):ENSDARG00000004105 (2)
GENE EXPRESSION
All Expression Data: 56 figures from 36 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2005 [eu718]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
DISEASE ASSOCIATED WITH tie1 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH tie1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000719 Protein kinase domain
Domain IPR000742 EGF-like domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Active_site IPR008266 Tyrosine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Conserved_site IPR013032 EGF-like, conserved site
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tie1-201 (1)    Ensembl 4348
Browsers: UCSCEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tie1 No data available
MARKER RELATIONSHIPS
tie1 Contained in: [BAC] CH73-185C24 (1), CH211-286N19 (1)
tie1 Encodes: [EST] eu718 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001346150 (1)
Genomic GenBank:CR936976 154888 bp
Select Tool
Polypeptide UniProtKB:A0A2R8Q2A9 (1) 1150 aa
Sequence Information (all 18)
ORTHOLOGY for tie1 ( Chr: 6 )
CITATIONS (87)