ZFIN ID: ZDB-GENE-990415-53
Gene Name: empty spiracles homeobox 3
Gene Symbol: emx3    Nomenclature History

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Previous Names: emx1 (1), zgc:110517

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in central nervous system projection neuron axonogenesis; early neuron differentiation in forebrain; and telencephalon development. Predicted to localize to the nucleus. Is expressed in several structures, including forebrain; forebrain neural plate; forebrain neural rod; neural keel; and periderm. Orthologous to human EMX1 (empty spiracles homeobox 1).
Genome Resources: Alliance (1),  Gene:30536 (1),  Ensembl(GRCz11):ENSDARG00000020417 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-emx3 N/A 2
MO2-emx3 N/A 1
MO3-emx3 N/A 1
MO4-emx3 N/A 1
DISEASE ASSOCIATED WITH emx3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH emx3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system projection neuron axonogenesis (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR020479 Homeobox domain, metazoa
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA emx3-201 (1)    Ensembl 2987
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM emx3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(emx3:emx3-MYC-GFP) emx3 emx3GFP Danio rerio 1 3
Tg(emx3:YFP) emx3 YFP Danio rerio 1 10
Tg(emx3:YFPm) emx3 YFP Danio rerio 1 4
Tg(hsp70l:emx3-MYC-GFP) hsp70l emx3GFP Danio rerio 1 5
MARKER RELATIONSHIPS
emx3 Contained in: [BAC] CH73-263G20 (1), DKEYP-110E4 (1)
emx3 Encodes: [EST] eu682 (1)
[cDNA] MGC:110517 (1), MGC:193008 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131279 (1) 1144 bp
Genomic GenBank:BX323077 (1) 195732 bp
Select Tool
Polypeptide UniProtKB:B2GTJ9 (1) 233 aa
Sequence Information (all 22)
ORTHOLOGY for emx3 ( Chr: 14 )
CITATIONS (99)