Gene

dlx5a

ID
ZDB-GENE-990415-49
Name
distal-less homeobox 5a
Symbol
dlx5a Nomenclature History
Previous Names
  • dlx4 (1)
  • zgc:101787
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; fin development; and olfactory nerve formation. Predicted to localize to nuclear chromatin. Is expressed in several structures, including fin; forebrain; pectoral fin bud; pharyngeal arch; and presumptive structure. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5).
Genome Resources
Note
None
Expression
All Expression Data
86 figures from 41 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlx5a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
split hand-foot malformation 1 Alliance Split-hand/foot malformation 1 183600
split hand-foot malformation 1 with sensorineural hearing loss Alliance ?Split-hand/foot malformation 1 with sensorineural hearing loss 220600
Associated With dlx5a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000047 Helix-turn-helix motif
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Domain IPR022135 Distal-less-like homeobox protein, N-terminal domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Distal-less-like homeobox protein, N-terminal domain Helix-turn-helix motif Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily
UniProtKB:Q5XJL9 282
UniProtKB:P50576 283
UniProtKB:B5DDT2 282
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations