ZFIN ID: ZDB-GENE-990415-49
Gene Name: distal-less homeobox 5a
Gene Symbol: dlx5a    Nomenclature History

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Previous Names: dlx4 (1), zgc:101787

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; fin development; and olfactory nerve formation. Predicted to localize to nucleus. Is expressed in several structures, including fin; forebrain; pectoral fin bud; pharyngeal arch; and presumptive structure. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5).
Genome Resources: Alliance (1),  Gene:30569 (1),  Ensembl(GRCz11):ENSDARG00000042296 (2)
GENE EXPRESSION
All Expression Data: 84 figures from 39 publications
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2004 [MGC:101787]
  7 figures (32 images) from Thisse et al., 2005 [eu348]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
j1073aGt Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13174 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39257 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlx5a N/A 7
    MO2-dlx5a N/A 4
    MO3-dlx5a N/A 2
    MO4-dlx5a N/A 2
    DISEASE ASSOCIATED WITH dlx5a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    split hand-foot malformation 1 Alliance Split-hand/foot malformation 1 183600
    split hand-foot malformation 1 with sensorineural hearing loss Alliance ?Split-hand/foot malformation 1 with sensorineural hearing loss 220600
    DISEASE ASSOCIATED WITH dlx5a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to mechanical stimulus (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlx5a-201 (1)    Ensembl 1302
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx5a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(1.1dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 1 2
    Tg(1.4dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 1 3
    Tg(dlx5a-dlx6a:ITETA) dlx5adlx6a Danio rerio 4 4
    Tg(dlx6a-1.4dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 0 35
    Tg(dlx6a-1.4dlx5a-dlx6a:mCherry) dlx5adlx6a mCherry Danio rerio 1 3
    MARKER RELATIONSHIPS
    dlx5a Contained in: [BAC] CH73-351F10 (1)
    dlx5a Encodes: [EST] eu348 (1)
    [cDNA] MGC:101787 (1), MGC:192790 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131306 (1) 1120 nt
    Genomic GenBank:CU929240 (1) 96118 nt
    Select Tool
    Polypeptide UniProtKB:P50576 (1) 283 aa
    Sequence Information (all 22)
    ORTHOLOGY for dlx5a ( Chr: 19 )
    CITATIONS (111)