Gene

raf1a

ID
ZDB-GENE-990415-41
Name
Raf-1 proto-oncogene, serine/threonine kinase a
Symbol
raf1a Nomenclature History
Previous Names
  • craf
  • raf1
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in activation of MAPKK activity and heart development. Predicted to localize to cytosol; mitochondrion; and plasma membrane. Is expressed in blastoderm; blastomere; and head. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 3 from Razzaque et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With raf1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1NN Alliance Cardiomyopathy, dilated, 1NN 615916
Noonan syndrome 5 Alliance Noonan syndrome 5 611553
Noonan syndrome with multiple lentigines 2 Alliance LEOPARD syndrome 2 611554
Associated With raf1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR003116 Raf-like Ras-binding
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain Details Per Protein
Protein Length Diacylglycerol/phorbol-ester binding Protein kinase, ATP binding site Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase domain Protein kinase-like domain superfamily Raf-like Ras-binding Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:A0A0R4IN14 643
UniProtKB:A0A0G2KD64 186
UniProtKB:D3KYU7 626
UniProtKB:A0A0R4IC76 291
UniProtKB:Q7ZTR8 643
UniProtKB:A0A0R4IC22 654
UniProtKB:F1QAD4 127
UniProtKB:Q6BE22 611
UniProtKB:Q90458 307
UniProtKB:Q7ZZW3 232
UniProtKB:Q76I87 255
UniProtKB:Q76FQ3 626
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations