ZFIN ID: ZDB-GENE-990415-37
Gene Name: complement component c3a, duplicate 3
Gene Symbol: c3a.3    Nomenclature History

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Previous Names: C3-3 (1), c3.3 (1), c3c, unp301

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to localize to extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
Genome Resources: Alliance (1),  Gene:565074 (1),  Ensembl(GRCz11):ENSDARG00000052207 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9572 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12504 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32793 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1164a Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-c3a.3 1
    MO1-c3a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH c3a.3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 9 Alliance {Macular degeneration, age-related, 9} 611378
    complement component 3 deficiency Alliance C3 deficiency 613779
    {Hemolytic uremic syndrome, atypical, susceptibility to, 5} 612925
    DISEASE ASSOCIATED WITH c3a.3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process complement activation (more)
    Cellular Component extracellular region (more)
    Molecular Function endopeptidase inhibitor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA c3a.3-201 (1)    Ensembl 5209
    Browsers: UCSCEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM c3a.3 No data available
    MARKER RELATIONSHIPS
    c3a.3 Contained in: [BAC] DKEY-121K17 (1) (order this)
    c3a.3 Has Artifact: [cDNA] MGC:103610
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001037236 (1) 5165 nt
    Genomic GenBank:AL928676 (1) 176196 nt
    Select Tool
    Polypeptide UniProtKB:F1R9X9 (1) 1654 aa
    Sequence Information (all 13)
    ORTHOLOGY for c3a.3 ( Chr: 1 )
    CITATIONS (33)