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ZIRC
ZFIN ID: ZDB-GENE-990415-261
Gene Name: IL2 inducible T cell kinase
Gene Symbol: itk    Nomenclature History

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Previous Names: Ptk, etID309877.14 (1), tec, ZFPtk

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in adaptive immune response; antigen receptor-mediated signaling pathway; and peptidyl-tyrosine autophosphorylation. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).
Genome Resources: Alliance (1),  Gene:798906 (1),  Ensembl(GRCz11):ENSDARG00000017565 (1)
GENE EXPRESSION
All Expression Data: text only from Haire et al., 1998
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa863 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-itk N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH itk HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lymphoproliferative syndrome 1 Alliance Lymphoproliferative syndrome 1 613011
    DISEASE ASSOCIATED WITH itk VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itk-201 (1)    Ensembl 2691
    itk-202 (1)    Ensembl 188
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itk No data available
    MARKER RELATIONSHIPS
    itk Contained in: [BAC] CH73-22O18 (1) (order this), DKEY-14M2 (1) (order this)
    itk Encodes: [cDNA] MGC:194051 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131104 (1) 2723 bp
    Genomic GenBank:BX088721 231054 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1R3M1 (1) 616 aa
    Sequence Clusters UniGene:75823 (1)
    Sequence Information (all 16)
    ORTHOLOGY for itk ( Chr: 14 )
    CITATIONS (24)