ZFIN ID: ZDB-GENE-990415-250
Gene Name: RAR-related orphan receptor C a
Gene Symbol: rorca    Nomenclature History

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Previous Names: rorc, rorg, NR1F3-A (1), RORgamma-A (1), RORgamma1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have several functions, including nuclear receptor activity; steroid hormone receptor activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in alar plate midbrain region; digestive system; midbrain hindbrain boundary neural rod; nervous system; and optic vesicle. Orthologous to human RORC (RAR related orphan receptor C).
Genome Resources: Alliance (1),  Gene:559245 (1),  Ensembl(GRCz11):ENSDARG00000057231 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH rorca HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency 42 616622
DISEASE ASSOCIATED WITH rorca VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003079 Nuclear receptor ROR
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rorca-201 (1)    Ensembl 2051
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rorca No data available
MARKER RELATIONSHIPS
rorca Contained in: [BAC] DKEY-192C10 (order this)
rorca Encodes: [EST] dq017627 (2)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001082819 (1) 1440 bp
Genomic GenBank:CR450766 (1) 132667 bp
Select Tool
Polypeptide UniProtKB:A0A2R8QJZ8 (1) 480 aa
Sequence Information (all 16)
ORTHOLOGY for rorca ( Chr: 8 )
CITATIONS (33)