ZFIN Gene: rx3

ZFIN ID: ZDB-GENE-990415-238

ZFIN ID: ZDB-GENE-990415-238

Gene Name:

retinal homeobox gene 3

Gene Symbol:

rx3

Sequence Ontology ID :

SO:0000704

Previous Names:

chk, chokh, eyes missing (1), eym (1)

Location:

Chr: 21 Mapping Details/Browsers

AUTOMATED DESCRIPTION

Predicted to have sequence-specific DNA binding activity. Involved in animal organ development and cell fate specification. Predicted to localize to the nucleus. Human ortholog(s) of this gene ...

GENE EXPRESSION
All Expression Data:	73 figures from 45 publications
Wild-type Stages, Structures:	Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
	anterior neural plate caudal hypothalamic zone diencephalon ventral region diencephalon forebrain ventral region forebrain forebrain neural keel forebrain neural plate hypothalamus anterior region hypothalamus immature eye lateral recess anatomical region lateral recess neural keel neural plate optic primordium optic vesicle preoptic area presumptive brain presumptive diencephalon ventral region presumptive diencephalon presumptive neural plate retina multi fate stem cell retina retinal inner nuclear layer telencephalon third ventricle anatomical region third ventricle unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu499	Point Mutation	Unknown	Missense	ENU
ne2611	Point Mutation	Exon 2	Missense	ENU
rx3_unspecified	Unspecified	Unknown	Unknown
s399	Point Mutation	Unknown	Premature Stop	ENU
sa29528	Point Mutation	Unknown	Splice Site	ENU
t25181	Point Mutation	Unknown	Missense	ENU	European Zebrafish Resource Center (EZRC) (order this)
t25327	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this)
w29	Point Mutation	Exon 2	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:

20 figures from 10 publications

Observed in:

DISEASE ASSOCIATED WITH rx3 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
isolated microphthalmia 3	Microphthalmia, isolated 3	611038

DISEASE ASSOCIATED WITH rx3 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	adenohypophysis development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 15)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001356 (1) InterPro:IPR003654 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1)	PROSITE:PS00027 (1) PROSITE:PS50071 (1) PROSITE:PS50803 (1)	Pfam:PF00046 (1) Pfam:PF03826 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	rx3-201 (1)	1411	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM rx3

Tg(rx3:Kaede)

MARKER RELATIONSHIPS

rx3Contained in:	[BAC] CH211-233A1 (1) (order this)
rx3Encodes:	[cDNA] MGC:195183 (1), MGC:195186 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131227 (1)	1322bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX248399 (1)	158884bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A8E7H4 (1)	292aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:540 (1)

Sequence Information (all 17)

OTHER rx3 GENE PAGES

Alliance (1)

Gene:30474 (1)

VEGA:OTTDARG00000018942 (1)

Ensembl(GRCz11):ENSDARG00000052893 (2)

ORTHOLOGY for rx3 (Chr: 21)

CITATIONS (112)

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