ZFIN ID: ZDB-GENE-990415-238
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Gene Name: retinal homeobox gene 3
Gene Symbol: rx3
Sequence Ontology ID : SO:0000704

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Previous Names: chk, chokh, eyes missing (1), eym (1)

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 72 figures from 44 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural plate, caudal hypothalamic zone, diencephalon (all 31) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu499 Point Mutation Unknown Unknown ENU
ne2611 Point Mutation Exon 2 Missense ENU
rx3_unspecified Unspecified Unknown Unknown
s399 Point Mutation Unknown Premature Stop ENU
sa29528 Point Mutation Unknown Splice Site ENU
t25181 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • t25327 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • w29 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents: MO1-rx3 (1), MO2-rx3 (1), MO3-rx3 (1)
    PHENOTYPE
    Data: 18 figures from 9 publications
    Observed in: adenohypophysis, adenohypophysis development, camera-type eye morphogenesis, caudal hypothalamic zone anterior region (all 28) expand
    DISEASE ASSOCIATED WITH rx3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    isolated microphthalmia 3 Microphthalmia, isolated 3 611038
    microphthalmia Microphthalmia, isolated 3 611038
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003654 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
    		•
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS50803 (1)
    		•
  • Pfam:PF00046 (1)
  • Pfam:PF03826 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA rx3-001 (1) 1411
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM rx3
    tg(rx3:kaede)
    MARKER RELATIONSHIPS
    rx3Contained in: [BAC] CH211-233A1 (1) (order this)
    rx3Encodes: [cDNA] MGC:195183 (1), MGC:195186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131227 (1) 1322bp
    Select Tool
    Genomic GenBank:BX248399 (1) 158884bp
    Select Tool
    Polypeptide UniProtKB:A8E7H4 (1) 292aa
    Select Tool
    Sequence Clusters UniGene:540 (1)
    Sequence Information (all 17)
    OTHER rx3 GENE PAGES
  • Alliance (1)
  • Gene:30474 (1)
  • VEGA:OTTDARG00000018942 (1)
  • Ensembl(GRCz10):ENSDARG00000052893 (1)
    • ORTHOLOGY for rx3 (Chr: 21)
    CITATIONS (105)