Gene

rx3

ID

ZDB-GENE-990415-238

Name

retinal homeobox gene 3

Symbol

rx3 Nomenclature History

Previous Names

chk
chokh
eyes missing (1)
eym (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within animal organ development and cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including forebrain; neural keel; neural plate; presumptive neural plate; and retina. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Orthologous to human RAX (retina and anterior neural fold homeobox).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

81 figures from 49 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 11 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rx3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isolated microphthalmia 3	Alliance	Microphthalmia, isolated 3	611038

Associated With rx3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR003654	OAR domain
Family	IPR043562	Retinal homeobox protein RAX/RAX2
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily