Gene

rx2

ID
ZDB-GENE-990415-237
Name
retinal homeobox gene 2
Symbol
rx2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in camera-type eye photoreceptor cell differentiation. Predicted to localize to nucleus. Is expressed in eye; immature eye; optic primordium; and presumptive diencephalon. Human ortholog(s) of this gene implicated in isolated microphthalmia 3. Orthologous to human RAX (retina and anterior neural fold homeobox).
Genome Resources
Note
None
Expression
All Expression Data
23 figures from 22 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. 6 from Nelson et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rx2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isolated microphthalmia 3 Alliance Microphthalmia, isolated 3 611038
Associated With rx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003654 OAR domain
Family IPR043562 Retinal homeobox protein RAX/RAX2
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily OAR domain Retinal homeobox protein RAX/RAX2
UniProtKB:Q504I7 137
UniProtKB:O42357 327
UniProtKB:F1QNV0 327
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations