ZFIN ID: ZDB-GENE-990415-235
Gene Name: recombination activating gene 2
Gene Symbol: rag2    Nomenclature History

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Previous Name: zgc:136743

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Contributes to double-stranded DNA endodeoxyribonuclease activity. Involved in immune system development and protein-DNA complex assembly. Localizes to DNA recombinase complex and endodeoxyribonuclease complex. Is expressed in immune system and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2).
Genome Resources: Alliance (1),  Gene:30658 (1),  Ensembl(GRCz11):ENSDARG00000052121 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb101 Indel Unknown Frameshift ZINC_FINGER_NUCLEASE
sa44245 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH rag2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Omenn syndrome Alliance Omenn syndrome 603554
    severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive Alliance Severe combined immunodeficiency, B cell-negative 601457
    Combined cellular and humoral immune defects with granulomas 233650
    DISEASE ASSOCIATED WITH rag2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein-DNA complex assembly (more)
    Cellular Component DNA recombinase complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rag2-201 (1)    Ensembl 2682
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rag2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rag2:DsRed) rag2 DsRed Danio rerio 1 11
    Tg(rag2:EGFP) rag2 EGFP Danio rerio 1 1
    Tg(rag2:EGFP-bcl2a) rag2 bcl2aEGFP Danio rerio 1 12
    Tg(rag2:EGFP-bcl2l1) rag2 bcl2l1EGFP Danio rerio 1 1
    Tg(rag2:EGFP-Hsa.ETV6-Hsa.RUNX1) rag2 EGFP Danio rerioHomo sapiens 1 2
    Tg(rag2:EGFP-Mmu.Myc) rag2 EGFP Danio rerioMus musculus 1 22
    Tg(rag2:GFP) rag2 GFP Danio rerio 2 34
    Tg(rag2:Hsa.ARID5B) rag2 Danio rerioHomo sapiens 1 1
    Tg(rag2:Hsa.ETV6-Hsa.RUNX1) rag2 Danio rerioHomo sapiens 1 2
    Tg(rag2:Hsa.GIMAP5,rag2:Hsa.GIMAP7,rag2:mCherry) rag2 mCherry Danio rerioHomo sapiens 1 1
    Tg(rag2:Hsa.MYC-ERT2) rag2 ERT2 Danio rerioMus musculus 1 12
    Tg(rag2:Hsa.NOTCH1-EGFP) rag2 EGFP Danio rerioHomo sapiens 1 4
    tg(rag2:jdp2b) rag2 jdp2b Danio rerio 1 1
    Tg(rag2:LOXP-DsRed2-LOXP-EGFP-Mmu.Myc) rag2 DsRed2EGFP Danio rerioMus musculus 1 10
    Tg(rag2:LOXP-DsRed2-LOXP-Hsa.KRAS_G12D) rag2 DsRed2 Danio rerioHomo sapiens 5 8
    Tg(rag2:mCherry) rag2 mCherry Danio rerio 1 1
    Tg(rag2:mCherry-badb) rag2 badbmCherry Danio rerio 1 1
    Tg(rag2:mCherry-badb_L99A) rag2 badbmCherry Danio rerio 1 1
    Tg(rag2:mCherry-bcl2a) rag2 bcl2amCherry Danio rerio 1 1
    Tg2(rag2:mCherry) rag2 mCherry Danio rerio 1 2
    Tg3(rag2:mCherry) rag2 mCherry Danio rerio 1 1
    tg4(rag2:mcherry) rag2 mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    rag2 Contained in: [BAC] CH211-256A21 (1)
    rag2 Encodes: [EST] fc85e11 (1)
    [cDNA] MGC:136743 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131385 (1) 2635 nt
    Genomic GenBank:AL935203 (1) 163572 nt
    Select Tool
    Polypeptide UniProtKB:O13034 (1) 530 aa
    Sequence Information (all 17)
    ORTHOLOGY for rag2 ( Chr: 25 )
    CITATIONS (93)