ZFIN ID: ZDB-GENE-990415-212
Gene Name: peroxisome proliferator-activated receptor delta a
Gene Symbol: pparda    Nomenclature History

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Previous Names: FAAR (1), PPAR[b], pparb, NR1C2-A (1), nr1c2a (1), NUC1 (1), PPARbeta-A (1), wu:fb60c11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in neural crest cell development and response to activity. Localizes to the chromatin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including intestine; liver; ovary; pectoral fin; and pharyngeal arch. Orthologous to human PPARD (peroxisome proliferator activated receptor delta).
Genome Resources: Alliance (1),  Gene:30750 (1),  Ensembl(GRCz11):ENSDARG00000044525 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 6 publications
Directly Submitted Expression Data: 7 figures (6 images) from Thisse et al., 2008 [af342937]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022432Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13252 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pparda N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pparda HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pparda VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to activity (more)
    Cellular Component chromatin (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 38)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Family IPR003074 Peroxisome proliferator-activated receptor
    Family IPR003075 Peroxisome proliferator-activated receptor, beta
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pparda-202 (1)    Ensembl 1735
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pparda No data available
    MARKER RELATIONSHIPS
    pparda Contained in: [BAC] CH73-352P18 (1)
    pparda Encodes: [EST] af342937 (1), fb60c11
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_694808 (1)
    Genomic GenBank:FP067424 (1) 87896 nt
    Select Tool
    Polypeptide UniProtKB:F8W3D2 (1) 496 aa
    Sequence Information (all 18)
    ORTHOLOGY for pparda ( Chr: 22 )
    CITATIONS (54)