ZFIN ID: ZDB-GENE-990415-211
Gene Name: peroxisome proliferator-activated receptor alpha b
Gene Symbol: pparab    Nomenclature History

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Previous Names: PPAR[a], ppara1 (1), ppara, pparal, nr1c1b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to cold and response to activity. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; female organism; immature eye; nervous system; and spinal cord neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
Genome Resources: Alliance (1),  Gene:557714 (1),  Ensembl(GRCz11):ENSDARG00000054323 (2)
GENE EXPRESSION
All Expression Data: 17 figures from 12 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2008 [dq017618]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pparab HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Hyperapobetalipoproteinemia, susceptibility to}
DISEASE ASSOCIATED WITH pparab VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to cold (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pparab-201 (1)    Ensembl 1590
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pparab No data available
MARKER RELATIONSHIPS
pparab Contained in: [BAC] CH211-218P2
pparab Encodes: [EST] dq017618 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001102567 (1) 1380 nt
Genomic GenBank:CR354430 (1) 197231 nt
Select Tool
Polypeptide UniProtKB:A6XMH7 (1) 459 aa
Sequence Information (all 17)
ORTHOLOGY for pparab ( Chr: 25 )
CITATIONS (85)