ZFIN ID: ZDB-GENE-990415-201
Gene Name: paired box 7a
Gene Symbol: pax7a    Nomenclature History

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Previous Names: pax7 (1), pax7c (1), pax7d (1), pax7e (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in developmental pigmentation; regulation of xanthophore differentiation; and wound healing. Localizes to nucleus. Is expressed in several structures, including central nervous system; muscle; neural crest; neural tube; and post-vent region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human PAX7 (paired box 7).
Genome Resources: Alliance (1),  Gene:30587 (1),  Ensembl(GRCz11):ENSDARG00000100398 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
oz19 Indel Unknown Unknown CRISPR
oz23 Indel Exon 2 Frameshift, Premature Stop CRISPR
sa14696 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35152 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41908 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • umu3 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pax7a 1
    MO1-pax7a N/A 2
    TALEN1-pax7a 1
    DISEASE ASSOCIATED WITH pax7a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma 2, alveolar 268220
    Myopathy, congenital, progressive, with scoliosis 618578
    DISEASE ASSOCIATED WITH pax7a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of xanthophore differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pax7a-201 (1)    Ensembl 2294
    pax7a-202 (1)    Ensembl 2377
    pax7a-203 (1)    Ensembl 1834
    pax7a-204 (1)    Ensembl 6932
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pax7a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(pax7a:EGFP) pax7a EGFP Danio rerio 1 4
    TgBAC(pax7a:GFP) pax7a GFP Danio rerio 1 6
    TgBAC(pax7a:LY-Tomato) pax7a Tomato Danio rerio 1 2
    MARKER RELATIONSHIPS
    pax7a Contained in: [BAC] CH73-132O13 (1), CH73-220M10 (1), CH211-168O24 (1)
    pax7a Encodes: [cDNA] MGC:195012 (1), MGC:195022 (1), MGC:195043 (1), MGC:195223 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131326 (1) 2403 nt
    Genomic GenBank:BX957335 (1) 168444 nt
    Select Tool
    Polypeptide UniProtKB:O57418 (1) 507 aa
    Sequence Information (all 48)
    ORTHOLOGY for pax7a ( Chr: 11 )
    CITATIONS (95)