Gene

ndr2

ID
ZDB-GENE-990415-181
Name
nodal-related 2
Symbol
ndr2 Nomenclature History
Previous Names
  • Ndr-2
  • cyc-1 (1)
  • cyc (1)
  • cyclops (1)
  • Znr-1
  • znr1
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have cytokine activity and type I activin receptor binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Predicted to localize to extracellular space. Is expressed in several structures, including axis; diencephalon; embryonic structure; forebrain neural keel; and mesoderm. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources
Note
None
Expression
All Expression Data
56 figures from 46 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
25 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ndr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
situs inversus Alliance Heterotaxy, visceral, 5 270100
Associated With ndr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:A0A2R8QUR2 501
UniProtKB:A0A0B5JK91 501
UniProtKB:P87358 501
UniProtKB:A0A0R4IZE5 505
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations