ZFIN ID: ZDB-GENE-990415-131
Gene Name: huntingtin
Gene Symbol: htt
Sequence Ontology ID : SO:0000704

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Previous Names: etID309952.1 (1), hd (1), ZHD (1)

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in several processes, including animal organ development, cellular iron ion homeostasis, and chordate embryonic development; predicted to localize to the cytoplasm and nucleus; used to study  ...
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12352 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15014 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19544 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19545 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38282 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39657 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39658 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39659 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45079 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko778a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • zko778b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC, ZKO consortium) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 15 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH htt HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Huntington's disease Huntington disease 143100
    Lopes-Maciel-Rodan syndrome 617435
    DISEASE ASSOCIATED WITH htt VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Huntington's disease WT + MO1-htt standard conditions Conforti et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior neural plate formation (more)
    Cellular Component cytoplasm (more)
    Molecular Function transcription factor binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000091 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR024613 (1)
  • InterPro:IPR028426 (1)
  • Pfam:PF12372 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA htt-201 (1) 10780
    antisense ottdart00000041370 (1) 902
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM htt No data available
    MARKER RELATIONSHIPS
    httContained in: [BAC] CH211-89O9 (1) (order this), DKEY-21K13 (1) (order this), DKEY-180B4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131018 (1) 10620bp
    Genomic GenBank:BX511019 (1) 180744bp
    Select Tool
    Polypeptide UniProtKB:B7ZDE9 (1) 3121aa
    Sequence Clusters UniGene:75813 (1)
    Sequence Information (all 28)
    OTHER htt GENE PAGES
  • Alliance (1)
  • Gene:30214 (1)
  • VEGA:OTTDARG00000019449 (1)
  • VEGA:OTTDARG00000030010 (1)
  • Ensembl(GRCz11):ENSDARG00000052866 (2)
  • ORTHOLOGY for htt (Chr: 1)
    CITATIONS (26)