Gene

hesx1

ID
ZDB-GENE-990415-130
Name
HESX homeobox 1
Symbol
hesx1 Nomenclature History
Previous Names
  • anf1 (1)
  • Anf (1)
  • anterior neural folds homolog
  • danf (1)
  • zanf
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have identical protein binding activity and sequence-specific DNA binding activity. Involved in forebrain development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in septooptic dysplasia. Is expressed in anterior presumptive neural plate; neural keel; neural plate; and telencephalon. Orthologous to human HESX1 (HESX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Young et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hesx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Growth hormone deficiency with pituitary anomalies 182230
Pituitary hormone deficiency, combined, 5 182230
Septooptic dysplasia 182230
Associated With hesx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Family IPR043402 Homeobox expressed in ES cells 1
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox expressed in ES cells 1
UniProtKB:P79738 161
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA hesx1-201 (1) Havana 420 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations