ZFIN ID: ZDB-GENE-990415-130
Gene Name: HESX homeobox 1
Gene Symbol: hesx1
Previous Names: anf1 (1), Anf (1), anterior neural folds homolog, danf (1), zanf
Location: Chr: 11 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 17 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2005 [eu608]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  anterior neural plate, anterior presumptive neural plate, forebrain neural keel antero-dorsal region, forebrain neural plate (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa14173 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-hesx1 (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hesx1 HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Growth hormone deficiency with pituitary anomalies 182230
    Septooptic dysplasia 182230
    Pituitary hormone deficiency, combined, 5 182230
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process forebrain development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hesx1-001 (1) 420
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hesx1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    hesx1Encodes: [EST] eu608 (1)
    [cDNA] MGC:193787 (1)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131349 (1) 717bp
    Genomic GenBank:CABZ01075842 (1) 27001bp
    Select Tool
    Polypeptide UniProtKB:B3DGX6 (1) 161aa
    Sequence Clusters UniGene:160293 (1)
    Sequence Information (all 16)
    OTHER hesx1 GENE PAGES 
  • Gene:30620 (1)
  • VEGA:OTTDARG00000043106 (1)
  • Ensembl(GRCz10):ENSDARG00000054509 (1)
  • ORTHOLOGY for hesx1 (Chr: 11) 
    Species Symbol Chromosome Accession # Evidence
    Human HESX1 3
  • Gene:8820
  • OMIM:601802
  • HGNC:4877
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (2)
    Mouse Hesx1 14
  • MGI:96071
  • Gene:15209
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (47)