Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-130
Gene Name: homeo box (expressed in ES cells) 1
Gene Symbol: hesx1
Previous Names: Anf (1), anterior neural folds homolog, danf (1), zanf
GENE EXPRESSION
All Expression Data: 22 figures from 14 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2005 [eu608]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  forebrain neural keel antero-dorsal region, neural keel, neural plate, presumptive telencephalon (all 6) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa14173
Knockdown reagents: MO1-hesx1 (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Growth hormone deficiency with pituitary anomalies 182230
Pituitary hormone deficiency, combined, 5 182230
Septooptic dysplasia 182230
GENE ONTOLOGY
Ontology GO Term
Biological Process forebrain development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM hesx1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hesx1 Encodes: [EST] eu608 (1)
    [cDNA] MGC:193787 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131349 (1) 717 bp
    Genomic GenBank:CABZ01075842 (1) 27001 bp
    Select Tool
    Polypeptide UniProtKB:B3DGX6 (1) 161 aa
    Sequence Clusters UniGene:226 (1)
    Sequence Information (all 16)
    OTHER hesx1 GENE PAGES
  • Gene:30620 (1)
  • Ensembl(Zv9):ENSDARG00000054509 (1)
  • MAPPING INFORMATION
    Chr: 11 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish hesx1 11  
    Human HESX1 3 (3p14.3)
  • OMIM:601802
  • Gene:8820
  • Mouse Hesx1 14 ( 16.09 cM)
  • MGI:96071
  • Gene:15209
  • CITATIONS (41)