ZFIN ID: ZDB-GENE-990415-130
Gene Name: HESX homeobox 1
Gene Symbol: hesx1
Previous Names: anf1 (1), Anf (1), anterior neural folds homolog, danf (1), zanf
Location: Chr: 11   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 17 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2005 [eu608]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  anterior neural plate, anterior presumptive neural plate, forebrain neural keel antero-dorsal region, forebrain neural plate (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-hesx1 (1)

Allele Type Mutagen Suppliers
sa14173 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Phenotype of Human Orthologue OMIM Phenotype ID
    Growth hormone deficiency with pituitary anomalies 182230
    Pituitary hormone deficiency, combined, 5 182230
    Septooptic dysplasia 182230
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process forebrain development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hesx1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hesx1 Encodes: [EST] eu608 (1)
    [cDNA] MGC:193787 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131349 (1) 717 bp
    Genomic GenBank:CABZ01075842 (1) 27001 bp
    Select Tool
    Polypeptide UniProtKB:B3DGX6 (1) 161 aa
    Sequence Clusters UniGene:160293 (1)
    Sequence Information (all 16)
    OTHER hesx1 GENE PAGES
  • Gene:30620 (1)
  • Ensembl(Zv9):ENSDARG00000054509 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hesx1 11  
    Human HESX1 3 (3p14.3)
  • OMIM:601802
  • Gene:8820
  • Mouse Hesx1 14 ( 16.09 cM)
  • MGI:96071
  • Gene:15209
  • Orthology Details
    CITATIONS (45)