ZFIN Gene: hoxb8a

ZFIN ID: ZDB-GENE-990415-108

ZFIN ID: ZDB-GENE-990415-108

Gene Name:

homeobox B8a

Gene Symbol:

hoxb8a Nomenclature History

Previous Names:

gp-8, hoxb8, fj67g02, wu:fj67g02 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 3 Mapping Details/Browsers

Description:

Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in cell population proliferation and posterior lateral line neuromast primordium migration. Predicted to localize to the nucleus. Is expressed in several structures, including nervous system; neural tube; pancreatic system; paraxial mesoderm; and pronephros. Orthologous to human HOXB8 (homeobox B8).

Genome Resources:

Alliance (1), Gene:30343 (1), Ensembl(GRCz11):ENSDARG00000056027 (2)

GENE EXPRESSION
All Expression Data:	12 figures from 6 publications
Directly Submitted Expression Data:	5 figures (8 images) from Thisse et al., 2004 [MGC:64159]
Wild-type Stages, Structures:	Segmentation:10-13 somites (14.0h-16.0h) to Hatching:Long-pec (48.0h-60.0h)
	central nervous system hindbrain lateral line system neural tube pancreas pancreas primordium pancreatic bud paraxial mesoderm pharyngeal arch 3-7 skeleton posterior lateral line placode posterior lateral line primordium posterior-most region posterior lateral line primordium pronephric duct pronephros spinal cord whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa14443	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-hoxb8a	N/A	2
MO2-hoxb8a	N/A	1

PHENOTYPE

Data:	2 figures from Breau et al., 2013
Observed in:	cell posterior lateral line neuromast primordium migration posterior lateral line primordium cell population proliferation posterior lateral line primordium posterior-most region

DISEASE ASSOCIATED WITH hoxb8a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH hoxb8a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cell population proliferation (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 8)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000047 (1) InterPro:IPR001356 (1) InterPro:IPR001827 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1) InterPro:IPR020479 (1)	PROSITE:PS00027 (1) PROSITE:PS00032 (1) PROSITE:PS50071 (1)	Pfam:PF00046 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	hoxb8a-201 (1)	1817	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ottdart00000001809 (1)	1752	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS

Addgene:Hox B8a

CONSTRUCTS WITH SEQUENCES FROM hoxb8a

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(5xUAS:hoxb8a-MYC,cryaa:RFP)	cryaa, UAS	hoxb8a, RFP	Danio rerio	1	4
Tg(5xUAS:hoxb8a-VP16,cryaa:RFP)	cryaa, UAS	hoxb8a, RFP	Danio rerio	1	3
Tg(5xUAS:hoxb8aDR-HA,cryaa:RFP)	cryaa, UAS	hoxb8a, RFP	Danio rerio	1	3

MARKER RELATIONSHIPS

hoxb8a Contained in:	[BAC] CH211-72A16 (1) (order this) [PAC] BUSM1-254O17 (1) (order this)
hoxb8a Encodes:	[EST] fj67g02 [cDNA] MGC:64159 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131120 (1)	1821 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927395 (1)	152987 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q8AWZ0 (1)	245 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:75787 (1)

Sequence Information (all 19)

ORTHOLOGY for hoxb8a ( Chr: 3 )

CITATIONS (48)

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