ZFIN ID: ZDB-GENE-990415-103
Gene Name: homeobox B2a
Gene Symbol: hoxb2a    Nomenclature History

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Previous Names: hoxb2, hm:zehn0229 (1), Z-151, zehn0229

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Is expressed in several structures, including hindbrain; hindbrain neural keel; hindbrain neural plate; neural crest; and pharyngeal arch. Orthologous to human HOXB2 (homeobox B2).
Genome Resources: Alliance (1),  Gene:30338 (1),  Ensembl(GRCz11):ENSDARG00000000175 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14119 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33161 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hoxb2a N/A 3
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hoxb2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hoxb2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR001827 Homeobox protein, antennapedia type, conserved site
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Domain IPR020479 Homeobox domain, metazoa
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hoxb2a-201 (1)    Ensembl 1832
    ottdart00000001812 (1) 1823
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM hoxb2a No data available
    MARKER RELATIONSHIPS
    hoxb2a Contained in: [BAC] DKEY-178D9 (1) (order this)
    [PAC] BUSM1-254O17 (2)
    hoxb2a Encodes: [EST] zehn0229
    [cDNA] MGC:76824 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131116 (1) 1844 nt
    Genomic GenBank:AL645782 (1) 119385 nt
    Select Tool
    Polypeptide UniProtKB:F1QMG2 (1) 409 aa
    Sequence Information (all 18)
    ORTHOLOGY for hoxb2a ( Chr: 3 )
    CITATIONS (71)