ZFIN ID: ZDB-GENE-990415-10
Gene Name: L1 cell adhesion molecule, paralog a
Gene Symbol: l1cama    Nomenclature History

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Previous Names: L1.2 (1), nadl1.2 (1), sb:eu320, sb:eu917, wu:fq26g05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of axon extension; and synapse organization. Predicted to localize to axonal growth cone; neuronal cell body; and plasma membrane. Is expressed in gut; nervous system; presumptive enteric nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule).
Genome Resources: Alliance (1),  Gene:30634 (1),  Ensembl(GRCz11):ENSDARG00000007149 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24359 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32448 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37742 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-l1cama N/A 1
    MO2-l1cama N/A 1
    DISEASE ASSOCIATED WITH l1cama HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hydrocephalus Alliance Hydrocephalus due to aqueductal stenosis 307000
    Hydrocephalus with congenital idiopathic intestinal pseudoobstruction 307000
    Hydrocephalus with Hirschsprung disease 307000
    MASA syndrome Alliance CRASH syndrome 303350
    MASA syndrome 303350
    Corpus callosum, partial agenesis of 304100
    DISEASE ASSOCIATED WITH l1cama VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of axon extension (more)
    Cellular Component axonal growth cone (more)
    Molecular Function axon guidance receptor activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA l1cama-201 (1)    Ensembl 4119
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM l1cama No data available
    MARKER RELATIONSHIPS
    l1cama Contained in: [BAC] DKEY-23G9 (1) (order this), DKEY-242A8 (1) (order this)
    l1cama Encodes: [EST] eu320 (1), eu917 (1), fq26g05 (1) (order this)
    [cDNA] MGC:193557 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131361 (1) 4119 nt
    Genomic GenBank:BX664745 (1) 261934 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DGN9 (1) 1271 aa
    Sequence Information (all 31)
    ORTHOLOGY for l1cama ( Chr: 23 )
    CITATIONS (41)