ZFIN ID: ZDB-GENE-980526-89
Gene Name: smoothened, frizzled class receptor
Gene Symbol: smo    Nomenclature History

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Previous Names: CHUNP6862, slow muscle omitted, smoh, smoothened (1), smu, wu:fb70b01, wu:fc39h03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits oxysterol binding activity. Involved in several processes, including animal organ development; blood vessel development; and nervous system development. Localizes to cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).
Genome Resources: Alliance (1),  Gene:30225 (1),  Ensembl(GRCz11):ENSDARG00000002952 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b577 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b641 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi229Tg Transgenic Insertion 5' UTR Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1640Tg Transgenic Insertion Exon 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2329bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • jj392 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la010329Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m841 Unknown Unknown Unknown ENU
    nv122 Point Mutation Unknown Premature Stop
    s294 Point Mutation Unknown Unknown
    sa38433 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • smo_unspecified Unspecified Unknown Unknown
    zf642 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-smo
    1
    CRISPR2-smo
    1
    CRISPR3-smo
    1
    MO1-smo N/A 1
    MO2-smo N/A 1
    MO3-smo N/A 1
    MO4-smo N/A 6
    MO5-smo N/A 1
    MO6-smo N/A 1
    MO7-smo N/A 1
    MO8-smo N/A 1
    PHENOTYPE
    Data: 96 figures from 59 publications
    Observed in:
    DISEASE ASSOCIATED WITH smo HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Basal cell carcinoma, somatic 605462
    Curry-Jones syndrome, somatic mosaic 601707
    Pallister-Hall-like syndrome 241800
    DISEASE ASSOCIATED WITH smo VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic camera-type eye development (more)
    Cellular Component cilium (more)
    Molecular Function oxysterol binding (more)
    GO Terms (all 76)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smo-201 (1)    Ensembl 6212
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smo
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(CMV:smo-EGFP) CMV EGFPsmo Danio rerio 1 2
    Tg(krt4:GAL4-VP16,14xUAS:smo-EGFP) krt4 EGFPGAL4smoVP16 Danio rerio 1 3
    Tg(krt5:GAL4-VP16,14xUAS:smo-EGFP) krt5UAS EGFPGAL4smoVP16 Danio rerio 1 3
    MARKER RELATIONSHIPS
    smo Contained in: [BAC] DKEY-180P18 (1) (order this)
    smo Encodes: [BAC END] zk11h20.sp6
    [EST] fb70b01 (1), fc39h03 (1)
    [cDNA] zv1 (1), zv2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131027 (1) 2880 nt
    Genomic GenBank:BX571796 (1) 130699 nt
    Select Tool
    Polypeptide UniProtKB:Q5RH73 (1) 822 aa
    Sequence Information (all 18)
    ORTHOLOGY for smo ( Chr: 4 )
    CITATIONS (264)