ZFIN ID: ZDB-GENE-980526-89
Gene Name: smoothened, frizzled class receptor
Gene Symbol: smo
Sequence Ontology ID : SO:0000704

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Previous Names: CHUNP6862, slow muscle omitted, smoh, smoothened (1), smu, wu:fb70b01, wu:fc39h03

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(Including Attributions)
Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 6 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Hatching:Long-pec (48.0h-60.0h)
  adaxial cell, axial mesoderm, brain dorsal region, brain nucleus (all 21) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b577 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b641 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi229Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1640Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi2329bTg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • jj392 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la010329Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m841 Unknown Unknown Unknown ENU
    nv122 Point Mutation Unknown Premature Stop
    s294 Point Mutation Unknown Unknown
    sa38433 Point Mutation Unknown Premature Stop ENU
    smo_unspecified Unspecified Unknown Unknown
    zf642 Unknown Unknown Unknown ENU
    Targeting reagents: CRISPR1-smo (1), MO1-smo (1), MO2-smo (1), MO3-smo (1), MO4-smo (1) (all 8) expand
    PHENOTYPE
    Data: 88 figures from 51 publications
    Observed in: adaxial cell, adenohypophyseal placode, anterior commissure astrocyte, anterior commissure (all 127) expand
    DISEASE ASSOCIATED WITH smo HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Basal cell carcinoma, somatic
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic camera-type eye development (more)
    Cellular Component cilium (more)
    Molecular Function oxysterol binding (more)
    GO Terms (all 74)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000539 (1)
  • InterPro:IPR015526 (1)
  • InterPro:IPR017981 (1)
  • InterPro:IPR020067 (1)
  • InterPro:IPR026544 (1)
  • InterPro:IPR035683 (1)
  • InterPro:IPR036790 (1)
  • PROSITE:PS50038 (1)
  • PROSITE:PS50261 (1)
  • Pfam:PF01392 (1)
  • Pfam:PF01534 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA smo-001 (1) 6212
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM smo
    Tg(CMV:smo-EGFP), Tg(krt4:GAL4-VP16,14xUAS:smo-EGFP), Tg(krt5:GAL4-VP16,14xUAS:smo-EGFP)
    MARKER RELATIONSHIPS
    smoContained in: [BAC] DKEY-180P18 (1) (order this)
    smoEncodes: [BAC END] zk11h20.sp6
    [EST] fb70b01 (1), fc39h03 (1)
    [cDNA] zv1 (1), zv2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131027 (1) 2880bp
    Genomic GenBank:BX571796 (1) 130699bp
    Select Tool
    Polypeptide UniProtKB:Q5RH73 (1) 822aa
    Sequence Clusters UniGene:114683 (1)
    Sequence Information (all 19)
    OTHER smo GENE PAGES
  • Alliance (1)
  • Gene:30225 (1)
  • VEGA:OTTDARG00000007795 (1)
  • Ensembl(GRCz10):ENSDARG00000002952 (1)
  • ORTHOLOGY for smo (Chr: 4)
    CITATIONS (241)