Gene

smo

ID
ZDB-GENE-980526-89
Name
smoothened, frizzled class receptor
Symbol
smo Nomenclature History
Previous Names
  • CHUNP6862
  • slow muscle omitted
  • smoh
  • smoothened (1)
  • smu
  • wu:fb70b01
  • wu:fc39h03
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Exhibits oxysterol binding activity. Involved in several processes, including animal organ development; blood vessel development; and nervous system development. Localizes to cilium. Is expressed in several structures, including brain; mesoderm; pectoral fin bud; tail bud; and trunk. Human ortholog(s) of this gene implicated in basal cell carcinoma and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
100 figures from 62 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smo Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Basal cell carcinoma, somatic 605462
Curry-Jones syndrome, somatic mosaic 601707
Pallister-Hall-like syndrome 241800
Associated With smo Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000539 Frizzled/Smoothened, transmembrane domain
Domain IPR017981 GPCR, family 2-like
Domain IPR020067 Frizzled domain
Domain IPR041771 Smoothened, cysteine-rich domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026544 Smoothened
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Frizzled/Smoothened, transmembrane domain GPCR, family 2-like Smoothened Smoothened, cysteine-rich domain
UniProtKB:Q5RH73 822
UniProtKB:Q90X26 822
UniProtKB:Q90YY4 808
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations