Gene

b2m

ID
ZDB-GENE-980526-88
Name
beta-2-microglobulin
Symbol
b2m Nomenclature History
Previous Names
  • bwm
  • wu:fa94c05
  • wu:fb10a09
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including antigen processing and presentation of peptide antigen via MHC class I; protein phosphorylation; and regulation of innate immune response. Predicted to localize to MHC class I protein complex; extracellular region; and integral component of membrane. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; inflammatory bowel disease; and primary immunodeficiency disease. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human B2M (beta-2-microglobulin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With b2m Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial visceral amyloidosis Alliance ?Amyloidosis, familial visceral 105200
immunodeficiency 43 Alliance Immunodeficiency 43 241600
Associated With b2m Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Domain IPR000488 Death domain
Domain IPR000719 Protein kinase domain
Domain IPR003597 Immunoglobulin C1-set
Domain IPR007110 Immunoglobulin-like domain
Domain IPR042747 IRAK3, death domain
Family IPR015707 Beta-2-Microglobulin
Family IPR033610 Interleukin-1 receptor-associated kinase 3
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Beta-2-Microglobulin Death domain Death-like domain superfamily Immunoglobulin C1-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin/major histocompatibility complex, conserved site Interleukin-1 receptor-associated kinase 3 IRAK3, death domain Protein kinase domain Protein kinase-like domain superfamily
UniProtKB:A0A2R8Q383 317
UniProtKB:A0A2R8Q583 330
UniProtKB:B0UYS1 116
UniProtKB:C5IG52 52
UniProtKB:Q04475 116
UniProtKB:H0WF44 112
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations