ZFIN ID: ZDB-GENE-980526-88
Gene Name: beta-2-microglobulin
Gene Symbol: b2m    Nomenclature History

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Previous Names: bwm, wu:fa94c05, wu:fb10a09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including MyD88-dependent toll-like receptor signaling pathway; negative regulation of innate immune response; and negative regulation of toll-like receptor signaling pathway. Predicted to localize to MHC class I protein complex; extracellular region; and integral component of membrane. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; inflammatory bowel disease; and primary immunodeficiency disease. Orthologous to human B2M (beta-2-microglobulin).
Genome Resources: Alliance (1),  Gene:30400 (1),  Ensembl(GRCz11):ENSDARG00000053136 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:77717]
  1 figure (1 image) from Thisse et al., 2005 [eu179]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33421 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH b2m HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial visceral amyloidosis Alliance ?Amyloidosis, familial visceral 105200
    Immunodeficiency 43 241600
    DISEASE ASSOCIATED WITH b2m VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process antigen processing and presentation of peptide antigen via MHC class I (more)
    Cellular Component extracellular region (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA b2m-201 (1)    Ensembl 1134
    b2m-202 (1)    Ensembl 844
    b2m-204 (1)    Ensembl 782
    ncRNA b2m-003 (1)    Ensembl 363
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM b2m No data available
    MARKER RELATIONSHIPS
    b2m Contained in: [BAC] DKEY-150I15 (1) (order this), DKEYP-87C9 (1)
    b2m Encodes: [EST] eu179 (1), fa94c05, fb10a09
    [cDNA] MGC:77717 (1), MGC:194148 (1), MGC:194174 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131163 (1) 1078 nt
    Genomic GenBank:CR558305 (1) 86313 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q583 (1) 330 aa
    Sequence Information (all 36)
    ORTHOLOGY for b2m ( Chr: 4 )
    CITATIONS (103)