ZFIN ID: ZDB-GENE-980526-79
Gene Name: hemoglobin, alpha adult 1
Gene Symbol: hbaa1    Nomenclature History

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Previous Name: AA1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to hypoxia. Predicted to localize to haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in eye; hematopoietic system; presumptive blood; and vasculature. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to several human genes including HBZ (hemoglobin subunit zeta).
Genome Resources: Alliance (1),  Gene:30507 (1),  Ensembl(GRCz11):ENSDARG00000097011 (1)
GENE EXPRESSION
All Expression Data: 30 figures from 13 publications
Directly Submitted Expression Data: 4 figures (3 images) from Thisse et al., 2004 [MGC:55446]
  11 figures (20 images) from Rauch et al., 2003 [fq14e12]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hbaa1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alpha thalassemia Alliance Thalassemias, alpha- 604131
familial erythrocytosis 7 Alliance Erythrocytosis, 7 617981
Heinz body anemia Alliance Heinz body anemias, alpha- 140700
hemoglobin H disease Alliance Hemoglobin H disease, nondeletional 613978
Methemoglobinemia, alpha type 617973
DISEASE ASSOCIATED WITH hbaa1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to hypoxia (more)
Cellular Component hemoglobin complex (more)
Molecular Function heme binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hbaa1-201 (1)    Ensembl 651
ottdart00000002411 (1) 581
ottdart00000002413 (1) 581
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hbaa1 No data available
MARKER RELATIONSHIPS
hbaa1 Contained in: [BAC] CH211-5K11 (1)
[PAC] BUSM1-118J2
hbaa1 Encodes: [EST] fq14e12 (1) (order this)
[cDNA] MGC:55446 (1), MGC:136224 (1), MGC:191622 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131257 (1) 597 nt
Genomic GenBank:AL935210 (1) 88933 nt
Select Tool
Polypeptide UniProtKB:Q1JQ69 (1) 143 aa
Sequence Information (all 28)
ORTHOLOGY for hbaa1 ( Chr: 3 )
CITATIONS (53)