ZFIN ID: ZDB-GENE-980526-73
Gene Name: distal-less homeobox 4a
Gene Symbol: dlx4a    Nomenclature History

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Previous Name: dlx8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; embryo development; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in gill and head. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4).
Genome Resources: Alliance (1),  Gene:30561 (1),  Ensembl(GRCz11):ENSDARG00000011956 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2124 Point Mutation Unknown Premature Stop ENU
sa40108 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlx4a N/A 1
    MO2-dlx4a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dlx4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    orofacial cleft 15 Alliance ?Orofacial cleft 15 616788
    DISEASE ASSOCIATED WITH dlx4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process multicellular organism development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlx4a-201 (1)    Ensembl 1195
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx4a No data available
    MARKER RELATIONSHIPS
    dlx4a Contained in: [BAC] CH211-35M4 (1), RP71-18K17 (1)
    dlx4a Encodes: [EST] eu468 (1)
    [cDNA] MGC:100782 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131300 (1) 1162 nt
    Genomic GenBank:AL590145 (1) 135675 nt
    Select Tool
    Polypeptide UniProtKB:Q6DBX9 (1) 250 aa
    Sequence Information (all 18)
    ORTHOLOGY for dlx4a ( Chr: 3 )
    CITATIONS (45)