ZFIN ID: ZDB-GENE-980526-55
Gene Name: Kruppel-like factor 1 (erythroid)
Gene Symbol: klf1    Nomenclature History

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Previous Names: klfd, zgc:194069

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in positive regulation of gene expression and primitive erythrocyte differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Orthologous to human KLF1 (Kruppel like factor 1).
Genome Resources: Alliance (1),  Gene:30104 (1),  Ensembl(GRCz11):ENSDARG00000017400 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 6 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2005 [eu650]
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-klf1 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH klf1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital dyserythropoietic anemia type IV Alliance Dyserythropoietic anemia, congenital, type IV 613673
Blood group--Lutheran inhibitor 111150
[Hereditary persistence of fetal hemoglobin] 613566
DISEASE ASSOCIATED WITH klf1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of gene expression (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA klf1-201 (1)    Ensembl 2525
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM klf1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(gata1a:EGFP-UTR-klfd) gata1a EGFPklf1UTR Danio rerio 10 2
MARKER RELATIONSHIPS
klf1 Contained in: [BAC] CH211-207J7 (1)
klf1 Encodes: [EST] eu650 (1)
[cDNA] MGC:194054 (1), MGC:194069 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_130936 (1) 2532 bp
Genomic GenBank:BX601645 (1) 223513 bp Blast at MegaBLAST
Polypeptide UniProtKB:Q90XE6 (1) 365 aa
Sequence Information (all 17)
ORTHOLOGY for klf1 ( Chr: 6 )
CITATIONS (29)