Gene

acvr2ba

ID
ZDB-GENE-980526-549
Name
activin A receptor type 2Ba
Symbol
acvr2ba Nomenclature History
Previous Names
  • actr2b
  • actrIIb
  • acvr2b
  • wu:fj97d11
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have activin binding activity and activin-activated receptor activity. Involved in cartilage development; hindbrain development; and neural crest cell migration. Predicted to localize to activin receptor complex. Is expressed in several structures, including blastomere; central nervous system; digestive system; gonad; and oral epithelium. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Albertson et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acvr2ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
visceral heterotaxy Alliance Heterotaxy, visceral, 4, autosomal 613751
Associated With acvr2ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ser/Thr protein kinase, TGFB receptor
UniProtKB:F1Q6M3 489
UniProtKB:A9CAY1 508
UniProtKB:F8W2D4 87
UniProtKB:Q4V965 509
UniProtKB:Q9YGU4 509
UniProtKB:F1QLL7 509
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations