ZFIN ID: ZDB-GENE-980526-527
Gene Name: activin A receptor type 1Ba
Gene Symbol: acvr1ba    Nomenclature History

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Previous Names: acvr1b, taram-a, tarama, alk4 (1), axis, wu:fb75f01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have activin binding activity and activin receptor activity, type I. Involved in dorsal/ventral pattern formation; fin regeneration; and formation of primary germ layer. Predicted to localize to activin receptor complex. Is expressed in several structures, including DEL; blastodisc; germ ring; margin; and presumptive shield. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ACVR1B (activin A receptor type 1B).
Genome Resources: Alliance (1),  Gene:30183 (1),  Ensembl(GRCz11):ENSDARG00000018968 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3475 Point Mutation Unknown Unknown ENU
hu3520 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12061 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12247 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-acvr1ba N/A 1
    PHENOTYPE
    Data: text only from Jazwinska et al., 2007
    Observed in:
    DISEASE ASSOCIATED WITH acvr1ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Pancreatic cancer, somatic
    DISEASE ASSOCIATED WITH acvr1ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endodermal cell fate determination (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acvr1ba-201 (1)    Ensembl 3789
    ncRNA acvr1ba-002 (1)    Ensembl 536
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acvr1ba
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:acvr1b_K234R-GFP) hsp70l acvr1baGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    acvr1ba Contained in: [BAC] CH211-169D8 (1)
    acvr1ba Encodes: [EST] fb75f01
    [cDNA] MGC:194749 (1), MGC:194782 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130990 (1) 1518 nt
    Genomic GenBank:CR387931 (1) 144701 nt
    Select Tool
    Polypeptide UniProtKB:B3DJ37 (1) 505 aa
    Sequence Information (all 20)
    ORTHOLOGY for acvr1ba ( Chr: 23 )
    CITATIONS (68)