Gene

stat1a

ID
ZDB-GENE-980526-499
Name
signal transducer and activator of transcription 1a
Symbol
stat1a Nomenclature History
Previous Names
  • stat1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to localize to cytoplasm and nucleus. Is expressed in blood; kidney; and spleen. Human ortholog(s) of this gene implicated in breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stat1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
chronic mucocutaneous candidiasis Alliance Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant 614162
immunodeficiency 31A Alliance Immunodeficiency 31A, mycobacteriosis, autosomal dominant 614892
immunodeficiency 31B Alliance Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive 613796
immunodeficiency 31C Alliance Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant 614162
Associated With stat1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Domain IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
Domain IPR035859 STAT1, SH2 domain
Family IPR001217 Transcription factor STAT
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding SH2 domain SH2 domain superfamily Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal STAT1, SH2 domain STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
UniProtKB:O93598 749
UniProtKB:Q6P943 749
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations