ZFIN ID: ZDB-GENE-980526-499
Gene Name: signal transducer and activator of transcription 1a
Gene Symbol: stat1a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and response to peptide hormone. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; primary immunodeficiency disease; and prostate adenocarcinoma. Is expressed in blood; kidney; and spleen. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
Genome Resources: Alliance (1),  Gene:30768 (1),  Ensembl(GRCz11):ENSDARG00000006266 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 8 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-stat1a
1
CRISPR2-stat1a
1
MO1-stat1a N/A 2
MO2-stat1a N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH stat1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
chronic mucocutaneous candidiasis Alliance Immunodeficiency 31C, autosomal dominant 614162
Immunodeficiency 31A, mycobacteriosis, autosomal dominant 614892
Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive 613796
DISEASE ASSOCIATED WITH stat1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component cytoplasm (more)
Molecular Function DNA binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000980 SH2 domain
Family IPR001217 Transcription factor STAT
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Domain IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal
Domain IPR035859 STAT1, SH2 domain
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA stat1a-201 (1)    Ensembl 4430
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM stat1a No data available
MARKER RELATIONSHIPS
stat1a Contained in: [BAC] DKEYP-84A8 (1)
stat1a Encodes: [cDNA] MGC:73305 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131480 (1) 2520 bp
Genomic GenBank:BX548072 (1) 188936 bp
Select Tool
Polypeptide UniProtKB:O93598 (1) 749 aa
Sequence Information (all 12)
ORTHOLOGY for stat1a ( Chr: 22 )
CITATIONS (49)