Gene

jak2a

ID
ZDB-GENE-980526-481
Name
Janus kinase 2a
Symbol
jak2a Nomenclature History
Previous Names
  • Jak2a kinase
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of receptor signaling pathway via JAK-STAT; and receptor signaling pathway via JAK-STAT. Predicted to localize to cytoskeleton and membrane. Is expressed in several structures, including cardiovascular system; erythroblast; hematopoietic system; nervous system; and yolk. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Orthologous to human JAK2 (Janus kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Ma et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jak2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
Budd-Chiari syndrome Alliance {Budd-Chiari syndrome, somatic} 600880
essential thrombocythemia Alliance Thrombocythemia 3 614521
familial erythrocytosis 1 Alliance Erythrocytosis, somatic 133100
myelofibrosis Alliance Myelofibrosis, somatic 254450
polycythemia vera Alliance Polycythemia vera, somatic 263300
Associated With jak2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR035589 Janus kinase 2, catalytic domain
Domain IPR035860 Tyrosine-protein kinase JAK2, SH2 domain
Domain IPR037838 JAK2, FERM domain C-lobe
Domain IPR041046 JAK, FERM F2 lobe domain
Domain IPR041155 FERM F1 lobe ubiquitin-like domain
Domain IPR041381 Jak1, pleckstrin homology-like domain
Family IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Band 4.1 domain FERM domain FERM F1 lobe ubiquitin-like domain FERM superfamily, second domain Jak1, pleckstrin homology-like domain JAK2, FERM domain C-lobe JAK, FERM F2 lobe domain Janus kinase 2, catalytic domain PH-like domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase JAK2, SH2 domain Tyrosine-protein kinase, non-receptor Jak/Tyk2
UniProtKB:F1QWX8 1095
UniProtKB:A0A286Y933 626
UniProtKB:A0A2R8Q9H8 50
UniProtKB:O93596 1095
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations