ZFIN ID: ZDB-GENE-980526-476
Gene Name: GATA binding protein 4
Gene Symbol: gata4    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development; cardiac muscle tissue regeneration; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including cardiac muscle myoblast; digestive system; mesoderm; pericardial region; and reproductive system. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4).
Genome Resources: Alliance (1),  Gene:30483 (1),  Ensembl(GRCz11):ENSDARG00000098952 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh320 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh321 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • gata4_unrecovered Point Mutation Unknown Unknown ENU
    sa44950 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa45720 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gata4
    2
    MO1-gata4 N/A 11
    MO2-gata4 N/A 3
    MO3-gata4 N/A 1
    MO4-gata4 N/A 1
    MO5-gata4 N/A 1
    DISEASE ASSOCIATED WITH gata4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 2 Alliance Atrial septal defect 2 607941
    atrioventricular septal defect Alliance Atrioventricular septal defect 4 614430
    tetralogy of Fallot Alliance Tetralogy of Fallot 187500
    ventricular septal defect Alliance Ventricular septal defect 1 614429
    ?Testicular anomalies with or without congenital heart disease 615542
    DISEASE ASSOCIATED WITH gata4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardioblast migration to the midline involved in heart field formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata4-201 (1)    Ensembl 1214
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-7.8gata4:GFP) gata4 GFP Danio rerio 1 5
    Tg(-11gata4:GFP) gata4 GFP Danio rerio 1 3
    Tg(-14.8gata4:ERT2-Cre-ERT2) gata4 CreERT2 Danio rerio 1 5
    Tg(-14.8gata4:GFP) gata4 GFP Danio rerio 2 21
    Tg(actb2:LOXP-TagBFP-LOXP-mCherry,dngata4) actb2 gata4mCherryTagBFP Danio rerio 1 4
    Tg(actb2:LOXP-TagBFP-LOXP-STOP-LOXP-gata4) actb2 gata4LOXPTagBFP Danio rerio 1 4
    Tg(gata4:DsRed2) gata4 DsRed2 Danio rerio 1 3
    Tg(hsp70l:Mmu.Mxi1-gata4,myl7:EGFP) hsp70lmyl7 EGFPgata4 Danio rerioMus musculus 1 3
    MARKER RELATIONSHIPS
    gata4 Contained in: [BAC] CH73-107C13 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131236 (1) 1173 nt
    Genomic GenBank:CU207296 (1) 98771 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILP3 (1) 352 aa
    Sequence Information (all 11)
    ORTHOLOGY for gata4 ( Chr: 20 )
    CITATIONS (151)