ZFIN ID: ZDB-GENE-980526-448
Gene Name: distal-less homeobox 6a
Gene Symbol: dlx6a    Nomenclature History

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Previous Name: dlx6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in medial fin morphogenesis and pectoral fin development. Predicted to localize to the nucleus. Is expressed in brain; head; and otic vesicle. Orthologous to human DLX6 (distal-less homeobox 6).
Genome Resources: Alliance (1),  Gene:30586 (1),  Ensembl(GRCz11):ENSDARG00000042291 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020833Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36900 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dlx6a N/A 3
    MO2-dlx6a N/A 3
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dlx6a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dlx6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process medial fin morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000047 Helix-turn-helix motif
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Domain IPR020479 Homeobox domain, metazoa
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlx6a-201 (1)    Ensembl 1629
    dlx6a-202 (1)    Ensembl 926
    dlx6a-203 (1)    Ensembl 867
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx6a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(1.1dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 1 2
    Tg(1.4dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 1 3
    Tg(dlx5a-dlx6a:ITETA) dlx5adlx6a Danio rerio 4 4
    Tg(dlx6a-1.4dlx5a-dlx6a:GFP) dlx5adlx6a GFP Danio rerio 0 35
    Tg(dlx6a-1.4dlx5a-dlx6a:mCherry) dlx5adlx6a mCherry Danio rerio 1 3
    Tg(nccr.i56i-i56ii-dlx6a:GFP) dlx6anccr.i56i-i56ii GFP Danio rerio 1 36
    tg(nccr.i56i-i56ii-dlx6a:kalta4) dlx6anccr.i56i-i56ii KALTA4 Danio rerio 1 1
    MARKER RELATIONSHIPS
    dlx6a Contained in: [BAC] CH73-351F10 (1)
    dlx6a Encodes: [cDNA] MGC:136749 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131323 (1) 1393 nt
    Genomic GenBank:CU929240 (1) 96118 nt
    Select Tool
    Polypeptide UniProtKB:Q29RC9 (1) 247 aa
    Sequence Information (all 15)
    ORTHOLOGY for dlx6a ( Chr: 19 )
    CITATIONS (78)