ZFIN ID: ZDB-GENE-980526-388
Gene Name: bone morphogenetic protein 2a
Gene Symbol: bmp2a    Nomenclature History

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Previous Names: bmp2, wu:fc59d09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have BMP receptor binding activity and cytokine activity. Involved in positive regulation of BMP signaling pathway. Predicted to localize to extracellular space. Is expressed in several structures, including brain; digestive system; fin; mesoderm; and visual system. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Orthologous to human BMP2 (bone morphogenetic protein 2).
Genome Resources: Alliance (1),  Gene:30631 (1),  Ensembl(GRCz11):ENSDARG00000013409 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bmp2a N/A 1
MO2-bmp2a N/A 1
MO3-bmp2a N/A 2
DISEASE ASSOCIATED WITH bmp2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type A2 Alliance Brachydactyly, type A2 112600
hemochromatosis type 1 Alliance {HFE hemochromatosis, modifier of} 235200
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 617877
DISEASE ASSOCIATED WITH bmp2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of BMP signaling pathway (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA bmp2a-201 (1)    Ensembl 1325
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM bmp2a No data available
MARKER RELATIONSHIPS
bmp2a Contained in: [Fosmid] CH1073-329C14 (1)
bmp2a Encodes: [EST] eu125 (1), fc59d09
[cDNA] MGC:194516 (1), MGC:194536 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131359 (1) 1161 nt
Genomic GenBank:CU929304 (1) 40935 nt
Select Tool
Polypeptide UniProtKB:A0A0B5GTK3 (1) 386 aa
Sequence Information (all 20)
ORTHOLOGY for bmp2a ( Chr: 17 )
CITATIONS (76)