ZFIN ID: ZDB-GENE-980526-347
Gene Name: LIM homeobox 1a
Gene Symbol: lhx1a    Nomenclature History

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Previous Names: lim1, lim1a (1), wu:fe25d04, wu:fj36b06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including animal organ development; gastrulation; and generation of neurons. Predicted to localize to nucleus and protein-containing complex. Is expressed in several structures, including axis; mesoderm; nervous system; renal system; and shield. Orthologous to human LHX1 (LIM homeobox 1).
Genome Resources: Alliance (1),  Gene:30463 (1),  Ensembl(GRCz11):ENSDARG00000014018 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb25 Indel Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa15189 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15800 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39051 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42561 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lhx1a N/A 1
    MO2-lhx1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lhx1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lhx1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellar Purkinje cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 42)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lhx1a-201 (1)    Ensembl 2402
    lhx1a-202 (1)    Ensembl 433
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lhx1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(lhx1a:EGFP) lhx1a EGFP Danio rerio 3 15
    MARKER RELATIONSHIPS
    lhx1a Contained in: [BAC] CH211-190N9 (1)
    lhx1a Encodes: [EST] eu502 (1), fe25d04, fj36b06
    [cDNA] MGC:194055 (1), MGC:194076 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131216 (1) 2243 nt
    Genomic GenBank:AL935164 (1) 170509 nt
    Select Tool
    Polypeptide UniProtKB:B3DGH2 (1) 405 aa
    Sequence Information (all 25)
    ORTHOLOGY for lhx1a ( Chr: 15 )
    CITATIONS (94)