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ZIRC
ZFIN ID: ZDB-GENE-980526-320
Gene Name: early growth response 1
Gene Symbol: egr1    Nomenclature History

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Previous Names: etID309970.14 (1), krox-24, krox24, wu:fj64b05, wu:fq25f01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have several functions, including DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in embryonic retina morphogenesis in camera-type eye and embryonic viscerocranium morphogenesis. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in asthma and myeloid neoplasm. Is expressed in head; heart; hindbrain neural keel; mesoderm; and nervous system. Orthologous to human EGR1 (early growth response 1).
Genome Resources: Alliance (1),  Gene:30498 (1),  Ensembl(GRCz11):ENSDARG00000037421 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa64 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa66 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa469 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42385 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-egr1
    1
    CRISPR2-egr1
    1
    MO1-egr1 N/A 1
    MO2-egr1 N/A 1
    MO3-egr1 N/A 1
    MO4-egr1 N/A 1
    MO5-egr1 N/A 1
    MO6-egr1 N/A 2
    DISEASE ASSOCIATED WITH egr1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH egr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye development (more)
    Cellular Component cytoplasm (more)
    Molecular Function double-stranded methylated DNA binding (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA egr1-201 (1)    Ensembl 3158
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM egr1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(egr1-Mmu.Fos:GFP) egr1 GFP Danio rerioMus musculus 2 2
    MARKER RELATIONSHIPS
    egr1 Contained in: [BAC] CH211-119C17 (1) (order this)
    egr1 Encodes: [EST] fj64b05, fq25f01 (1) (order this)
    [cDNA] MGC:195300 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131248 (1) 1536 bp
    Genomic GenBank:BX324111 (1) 163871 bp
    Select Tool
    Polypeptide UniProtKB:B3DKJ7 (1) 511 aa
    Sequence Clusters UniGene:144146 (1)
    Sequence Information (all 23)
    ORTHOLOGY for egr1 ( Chr: 14 )
    CITATIONS (71)