Gene

ikzf1

ID
ZDB-GENE-980526-304
Name
IKAROS family zinc finger 1 (Ikaros)
Symbol
ikzf1 Nomenclature History
Previous Names
  • ikaros (1)
  • znfn1a1 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and transcription regulatory region sequence-specific DNA binding activity. Involved in B cell differentiation and T cell differentiation in thymus. Predicted to localize to nucleoplasm. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human IKZF1 (IKAROS family zinc finger 1).
Genome Resources
Note
None
Expression
All Expression Data
77 figures from 55 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Hess et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ikzf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Immunodeficiency, common variable, 13 616873
Associated With ikzf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations