Gene

raraa

ID
ZDB-GENE-980526-284
Name
retinoic acid receptor, alpha a
Symbol
raraa Nomenclature History
Previous Names
  • rara2a (1)
  • rara
  • zRAR
  • zrara
  • etID309833.12 (1)
  • NR1B1-A (1)
  • nr1b1a (1)
  • RARalpha-A (1)
  • zgc:109797
  • zRAR-alpha-2.A
  • zRAR-alpha
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits nuclear receptor activity. Involved in hindbrain morphogenesis; liver development; and response to retinoic acid. Predicted to localize to nucleus. Is expressed in several structures, including endoderm; gonad; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung cancer (multiple); and syndromic microphthalmia 12. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
Genome Resources
Note
None
Expression
All Expression Data
40 figures from 16 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Garnaas et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With raraa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute promyelocytic leukemia Alliance Leukemia, acute promyelocytic 612376
Associated With raraa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003078 Retinoic acid receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Retinoic acid receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q90271 444
UniProtKB:T2DKU4 447
UniProtKB:A0A0R4IDZ9 83
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations