ZFIN ID: ZDB-GENE-980526-284
Gene Name: retinoic acid receptor, alpha a
Gene Symbol: raraa    Nomenclature History

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Previous Names: rara2a (1), rara, zRAR, zrara, etID309833.12 (1), NR1B1-A (1), nr1b1a (1), RARalpha-A (1), zgc:109797, zRAR-alpha-2.A, zRAR-alpha

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits nuclear receptor activity. Involved in hindbrain morphogenesis; liver development; and response to retinoic acid. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including endoderm; gonad; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung cancer (multiple); and syndromic microphthalmia 12. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
Genome Resources: Alliance (1),  Gene:30680 (1),  Ensembl(GRCz11):ENSDARG00000056783 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31860 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-raraa N/A 4
    MO2-raraa N/A 1
    MO3-raraa N/A 1
    PHENOTYPE
    Data: Fig. 3 from Garnaas et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH raraa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute promyelocytic leukemia Alliance Leukemia, acute promyelocytic 612376
    DISEASE ASSOCIATED WITH raraa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hindbrain morphogenesis (more)
    Cellular Component host cell nucleus (more)
    Molecular Function nuclear receptor activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA raraa-201 (1)    Ensembl 2492
    raraa-203 (1)    Ensembl 638
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM raraa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:dnraraa-EGFP) hsp70l EGFPraraa Danio rerio 2 5
    Tg(ubb:LOXP-ECFP-LOXP-dnraraa-EGFP) ubb ECFPEGFPraraa Danio rerio 1 3
    MARKER RELATIONSHIPS
    raraa Contained in: [BAC] DKEY-56E5 (1) (order this)
    raraa Encodes: [EST] rar-alpha-2 (1) (order this), s74155 (1)
    [cDNA] MGC:109797 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131406 (1) 2197 nt
    Genomic GenBank:BX890609 (1) 228713 nt Blast at MegaBLAST
    Polypeptide UniProtKB:T2DKU4 (1) 447 aa
    Sequence Information (all 23)
    ORTHOLOGY for raraa ( Chr: 12 )
    CITATIONS (78)