ZFIN ID: ZDB-GENE-980526-27
Gene Name: orthodenticle homeobox 2a
Gene Symbol: otx2a    Nomenclature History

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Previous Names: otx1a, otx1l, otx3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in brain development and retinal pigment epithelium development. Predicted to localize to nucleus. Is expressed in several structures, including anterior neural keel; axis; brain; immature eye; and neural plate. Orthologous to human OTX1 (orthodenticle homeobox 1).
Genome Resources: Alliance (1),  Gene:30462 (1),  Ensembl(GRCz11):ENSDARG00000030703 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12472 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19590 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko985a Small Deletion Unknown Unknown CRISPR
    zko985b Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-otx2a 1
    MO1-otx2a N/A 5
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH otx2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH otx2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA otx2a-201 (1)    Ensembl 1629
    ncRNA otx1a-002 (1)    Ensembl 583
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM otx2a No data available
    MARKER RELATIONSHIPS
    otx2a Contained in: [BAC] DKEYP-123H10 (1)
    otx2a Encodes: [EST] eu812 (1)
    [cDNA] MGC:100760 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131215 (1) 1660 nt
    Genomic GenBank:BX855617 (1) 160094 nt
    Select Tool
    Polypeptide UniProtKB:Q90267 (1) 338 aa
    Sequence Information (all 13)
    ORTHOLOGY for otx2a ( Chr: 1 )
    CITATIONS (51)