ZFIN ID: ZDB-GENE-980526-227
Gene Name: activin A receptor type 2Aa
Gene Symbol: acvr2aa    Nomenclature History

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Previous Names: actr2a (1), acvr2, acvr2a, etID22865.9 (1), wu:fa02e10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have several functions, including activin binding activity; transforming growth factor beta receptor activity, type II; and type I transforming growth factor beta receptor binding activity. Involved in cartilage development; hindbrain development; and neural crest cell migration. Predicted to localize to the activin receptor complex. Human ortholog(s) of this gene implicated in colon cancer. Is expressed in several structures, including blastoderm; blastomere; gut; oral region; and ovarian follicle. Orthologous to human ACVR2A (activin A receptor type 2A).
Genome Resources: Alliance (1),  Gene:553359 (1),  Ensembl(GRCz11):ENSDARG00000011188 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34653 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34654 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-acvr2aa
    2
    CRISPR2-acvr2aa
    2
    MO1-acvr2aa N/A 1
    MO2-acvr2aa N/A 1
    DISEASE ASSOCIATED WITH acvr2aa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH acvr2aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Domain IPR000472 Activin types I and II receptor domain
    Domain IPR000719 Protein kinase domain
    Family IPR000333 Ser/Thr protein kinase, TGFB receptor
    Family IPR017194 Transforming growth factor-beta receptor, type II
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acvr2aa-203 (1)    Ensembl 5124
    ncRNA acvr2aa-002 (1)    Ensembl 539
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acvr2aa No data available
    MARKER RELATIONSHIPS
    acvr2aa Contained in: [BAC] CH211-260F1 (1)
    acvr2aa Encodes: [EST] fa02e10
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110278 (1) 3273 nt
    Genomic GenBank:BX571777 (1) 155958 nt
    Select Tool
    Polypeptide UniProtKB:F1R4D0 (1) 538 aa
    Sequence Information (all 23)
    ORTHOLOGY for acvr2aa ( Chr: 9 )
    CITATIONS (45)