Gene
ascl1b
- ID
- ZDB-GENE-980526-174
- Name
- achaete-scute family bHLH transcription factor 1b
- Symbol
- ascl1b Nomenclature History
- Previous Names
-
- ashb
- Zash-1b (1)
- zashb
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to contribute to DNA-binding transcription factor activity. Involved in chordate embryonic development; endocrine pancreas development; and hindbrain morphogenesis. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; neural plate; neural tube; neurons; and posterior neural keel. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to several human genes including ASCL2 (achaete-scute family bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu104 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR015660 | Achaete-scute transcription factor-related |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR025875 | Leucine rich repeat 4 |
Domain Details Per Protein
| Protein | Length | Achaete-scute transcription factor-related | C-terminal of Roc (COR) domain | Helix-loop-helix DNA-binding domain superfamily | Leucine-rich repeat | Leucine rich repeat 4 | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Myc-type, basic helix-loop-helix (bHLH) domain | P-loop containing nucleoside triphosphate hydrolase | Roc domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90260
|
195 | |||||||||||
|
UniProtKB:E7F965
|
829 | |||||||||||
|
UniProtKB:A0A2R8S0I4
|
863 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
ascl1b-203
(1)
|
1273 nt |
Interactions and Pathways
No data available
Plasmids
No data available