ZFIN ID: ZDB-GENE-980526-166
Gene Name: sonic hedgehog a
Gene Symbol: shha
Previous Names: shh, fc83d08, sonic you, sonic-you (1), syu, vertebrate hedgehog homolog (1), vhh1 (1), wu:fc83d08 (1)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 402 figures from 302 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  anal fin, anterior neural keel, anterior neural keel ventral region, anterior neural rod (all 134) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
shha_unspecified Unspecified Unknown Unknown
t4 Deficiency Unknown Unknown SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • tbq70 Unknown Unknown Unknown ENU
    tbx392 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq252 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-shha (1), MO2-shha (1), MO3-shha (1), MO4-shha (1)
    PHENOTYPE
    Data: 54 figures from 36 publications
    Observed in: adaxial cell, adenohypophysis development, anatomical system, apical ectodermal ridge pectoral fin bud (all 87) expand
    DISEASE ASSOCIATED WITH shha HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    holoprosencephaly Holoprosencephaly 3 142945
    Microphthalmia with coloboma 5 611638
    Single median maxillary central incisor 147250
    Schizencephaly 269160
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 65)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR006141 (1)
  • InterPro:IPR009045 (1)
  • InterPro:IPR028992 (1)
  • PROSITE:PS50817 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shha-001 (1) 4551
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM shha
    Tg(-2.4shha-A:GFP), Tg(-2.4shha-AB:GFP), Tg(-2.4shha-ABC:DsRed), Tg(-2.4shha-ABC:DsRed.T4), Tg(-2.4shha-ABC:GFP) (all 23) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shhaContained in: [BAC] CH211-105D1 (1) (order this), CH211-150E22 (1) (order this)
    shhaEncodes: [EST] fc83d08
    [cDNA] MGC:194075 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131063 (1) 2602bp
    Genomic GenBank:CU041319 (1) 174262bp
    Select Tool
    Polypeptide UniProtKB:A0A0B5JF88 (1) 418aa
    Sequence Clusters UniGene:115833 (1)
    Sequence Information (all 39)
    OTHER shha GENE PAGES
  • Gene:30269 (1)
  • VEGA:OTTDARG00000035495 (1)
  • Ensembl(GRCz10):ENSDARG00000068567 (1)
  • ORTHOLOGY for shha (Chr: 7)
    Species Symbol Chromosome Accession # Evidence
    Human SHH 7
  • Gene:6469
  • OMIM:600725
  • HGNC:10848
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (4)
    Mouse Shh 5
  • MGI:98297
  • Gene:20423
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (2)
    Download Curated Orthology
    CITATIONS (703)