ZFIN Gene: shha

ZFIN ID: ZDB-GENE-980526-166

ZFIN ID: ZDB-GENE-980526-166

Gene Name:

sonic hedgehog signaling molecule a

Gene Symbol:

shha

Sequence Ontology ID :

SO:0000704

Previous Names:

shh, fc83d08, sonic you, sonic-you (1), syu, vertebrate hedgehog homolog (1), vhh1 (1), wu:fc83d08 (1)

Location:

Chr: 7 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and neurogenesis. ...

GENE EXPRESSION
All Expression Data:	445 figures from 334 publications
Wild-type Stages, Structures:	Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
	anal fin anterior neural keel ventral region anterior neural keel anterior neural rod axial chorda mesoderm axial mesoderm axis basal plate midbrain region blastema brain ventral region brain caudal fin lepidotrichium central nervous system ventral region central nervous system chordo neural hinge cloaca diencephalon anterior region diencephalon posterior region diencephalon ventral region diencephalon dorsal fin lepidotrichium endoderm epidermal basal stratum epidermis esophagus eye fin fin bud floor plate floor plate diencephalic region floor plate neural rod floor plate neural tube floor plate rhombomere region floor plate spinal cord region forebrain anterior region forebrain ventral region forebrain forebrain midbrain boundary forebrain neural keel forebrain neural rod gill gut endoderm gut endodermal cell gut epithelial cell gut gut endothelial cell gut epithelium head hindbrain floor plate hindbrain notochord hindbrain hindbrain neural plate hypoblast hypochord hypothalamus anterior region hypothalamus antero-dorsal region hypothalamus medial region hypothalamus posterior region hypothalamus intestinal bulb epithelium intestinal bulb primordium anterior-most region lateral floor plate mandibular arch skeleton medial floor plate mesenchyme pectoral fin mesoderm mesoderm pectoral fin bud mid diencephalic organizer central region mid diencephalic organizer dorsal region mid diencephalic organizer ventral region mid diencephalic organizer midbrain ventral region midbrain mouth ectoderm neural crest neural keel ventral region neural keel neural plate neural rod neural tube ventral region neurocranium neuroectoderm antero-ventral region neuroectoderm ventral region neuroectoderm notochord distal region notochord posterior side notochord notochord posterior region optic stalk optic tectum oral ectoderm oral epithelium oral region ectoderm oral region pectoral fin pectoral fin bud anterior margin pectoral fin bud posterior margin pectoral fin bud posterior region pectoral fin bud pectoral fin lepidotrichium pectoral fin musculature pelvic fin lepidotrichium pharyngeal arch endoderm pharyngeal arch 2 pharyngeal endoderm pharyngeal epithelium pharyngeal pouch 1 pharynx endoderm pharynx pneumatic duct postcranial axial cartilage prechordal plate preoptic area presumptive diencephalon presumptive dorsal mesoderm presumptive floor plate presumptive shield presumptive swim bladder pretectum proctodeum regenerating fin retina retinal ganglion cell serotonergic neuron shield somite spinal cord spinal cord neural keel spinal cord neural tube stomodeum swim bladder epithelium swim bladder swim bladder bud epithelium swim bladder bud tail bud tegmentum telencephalon thalamus third ventricle anatomical region unspecified whole organism zona limitans intrathalamica zone of polarizing activity pectoral fin bud
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
shha_unspecified	Unspecified	Unknown	Unknown
t4	Deficiency	Unknown	Unknown	SPONTANEOUS	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tbq70	Unknown	Unknown	Unknown	ENU
tbx392	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tq252	Point Mutation	Unknown	Unknown		European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
vcc8Gt	Transgenic Insertion	Intron 1	Unknown	DNA_AND_TALEN

Targeting reagents:

PHENOTYPE

Data:

30 figures from 19 publications

Observed in:

DISEASE ASSOCIATED WITH shha HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
holoprosencephaly 3	Holoprosencephaly 3	142945
	Schizencephaly	269160
	Microphthalmia with coloboma 5	611638
	Single median maxillary central incisor	147250

DISEASE ASSOCIATED WITH shha VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	adenohypophysis development (more)
Cellular Component	membrane (more)
Molecular Function	hydrolase activity (more)

GO Terms (all 70)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000320 (1) InterPro:IPR001657 (1) InterPro:IPR001767 (1) InterPro:IPR003586 (1) InterPro:IPR003587 (1) InterPro:IPR006141 (1) InterPro:IPR009045 (1) InterPro:IPR036844 (1)	PROSITE:PS50817 (1)	Pfam:PF01079 (1) Pfam:PF01085 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	shha-201 (1)	4551	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	ottdart00000022325 (1)	2608	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIESNo data available

PLASMIDS

Addgene

CONSTRUCTS WITH SEQUENCES FROM shha

MARKER RELATIONSHIPS

shhaContained in:	[BAC] CH211-105D1 (1) (order this), CH211-150E22 (1) (order this)
shhaEncodes:	[EST] fc83d08 [cDNA] MGC:194075 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131063 (1)	2600bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU041319 (1)	174262bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0B5JF88 (1)	418aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:115833 (1)

Sequence Information (all 38)

OTHER shha GENE PAGES

Alliance (1)

Gene:30269 (1)

VEGA:OTTDARG00000035495 (1)

Ensembl(GRCz11):ENSDARG00000068567 (1)

ORTHOLOGY for shha (Chr: 7)

CITATIONS (807)

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