ZFIN ID: ZDB-GENE-980526-166
Gene Name: sonic hedgehog signaling molecule a
Gene Symbol: shha    Nomenclature History

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Previous Names: shh, fc83d08, sonic you, sonic-you (1), syu, vertebrate hedgehog homolog (1), vhh1 (1), wu:fc83d08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and neurogenesis. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; basal cell carcinoma; holoprosencephaly (multiple); middle cerebral artery infarction; and polydactyly. Is expressed in several structures, including central nervous system; digestive system; fin; head; and mesoderm. Orthologous to human SHH (sonic hedgehog signaling molecule).
Genome Resources: Alliance (1),  Gene:30269 (1),  Ensembl(GRCz11):ENSDARG00000068567 (1)
GENE EXPRESSION
All Expression Data: 447 figures from 336 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
shha_unspecified Unspecified Unknown Unknown
t4 Deficiency Unknown Unknown SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • tbq70 Unknown Unknown Unknown ENU
    tbx392 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq252 Point Mutation Unknown Unknown
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vcc8Gt Transgenic Insertion Intron 1 Unknown DNA_AND_TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-shha N/A 19
    MO2-shha N/A 1
    MO3-shha N/A 1
    MO4-shha N/A 2
    MO5-shha N/A 1
    MO6-shha N/A 1
    MO7-shha N/A 1
    TALEN1-shha 1
    TALEN2-shha
    1
    TALEN3-shha
    1
    DISEASE ASSOCIATED WITH shha HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 3 Alliance Holoprosencephaly 3 142945
    solitary median maxillary central incisor Alliance Single median maxillary central incisor 147250
    Microphthalmia with coloboma 5 611638
    Schizencephaly 269160
    DISEASE ASSOCIATED WITH shha VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 70)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000320 Hedgehog, N-terminal signalling domain
    Family IPR001657 Hedgehog protein
    Domain IPR001767 Hedgehog protein, Hint domain
    Domain IPR003586 Hint domain C-terminal
    Domain IPR003587 Hint domain N-terminal
    PTM IPR006141 Intein N-terminal splicing region
    Homologous_superfamily IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
    Homologous_superfamily IPR036844 Hint domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA shha-201 (1)    Ensembl 4551
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM shha
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.4shha-A:GFP) shha GFP Danio rerio 2 5
    Tg(-2.4shha-AB:GFP) shha GFP Danio rerio 1 3
    Tg(-2.4shha-ABC:DsRed) shha DsRed Danio rerio 1 3
    Tg(-2.4shha-ABC:DsRed.T4) shha DsRed Danio rerio 1 2
    Tg(-2.4shha-ABC:GFP) shha GFP Danio rerio 4 42
    Tg(-2.4shha-AC:GFP) shha GFP Danio rerio 1 3
    Tg(-2.4shha-B:GFP) shha GFP Danio rerio 2 5
    Tg(-2.4shha-BC:GFP) shha GFP Danio rerio 3 3
    Tg(-2.4shha-C:GFP) shha GFP Danio rerio 2 5
    Tg(-2.4shha-E1:GFP) shhasox9a GFP Danio rerio 1 2
    Tg(-2.4shha-M12:GFP) shha GFP Danio rerio 1 2
    Tg(-2.4shha-M13:GFP) shha GFP Danio rerio 1 2
    Tg(-2.4shha:GFP) shha GFP Danio rerio 1 7
    Tg(-2.7shha:GFP) shha GFP Danio rerio 1 20
    Tg(hsp70l:shha-EGFP) hsp70l EGFPshha Danio rerio 1 7
    Tg(krt18a.1:shha-RFP) krt18a.1 RFPshha Danio rerio 1 3
    Tg(shha-gata2a:GAL4-VP16) gata2ashha GAL4VP16 Danio rerio 1 1
    Tg(shha:ccbe1,TagRFP) shha ccbe1TagRFP Danio rerio 1 3
    Tg(shha:GAL4FF) shha GAL4FF Danio rerio 1 3
    Tg(shha:h2az2a-EGFP) shha EGFPh2az2a Danio rerio 1 1
    Tg(shha:vegfc,mTurquoise) shha mTurquoisevegfc Danio rerio 1 4
    tg(tetre:shha-mcherry,myl7:egfp) myl7TETRE EGFPmCherryshha Danio rerio 0 1
    Tg(UAS:EGFP,UAS:shha) UAS EGFPshha Danio rerio 1 4
    Tg(UAS:shha) UAS shha Danio rerio 1 3
    Tg(UAS:shha,myl7:EGFP) myl7 EGFPshha Danio rerio 2 3
    Tg(UAS:shha-EGFP,Xla.Cry1:GFP) EGFPGFPshha Danio rerioXenopus laevis 1 2
    MARKER RELATIONSHIPS
    shha Contained in: [BAC] CH211-105D1 (1), CH211-150E22 (1)
    shha Encodes: [EST] fc83d08
    [cDNA] MGC:194075 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131063 (1) 2600 bp
    Genomic GenBank:CU041319 (1) 174262 bp
    Select Tool
    Polypeptide UniProtKB:A0A0B5JF88 (1) 418 aa
    Sequence Clusters UniGene:115833 (1)
    Sequence Information (all 38)
    ORTHOLOGY for shha ( Chr: 7 )
    CITATIONS (815)