ZFIN Gene: shha

ZFIN ID: ZDB-GENE-980526-166

ZFIN ID: ZDB-GENE-980526-166

Gene Name:

sonic hedgehog signaling molecule a

Gene Symbol:

shha Nomenclature History

Previous Names:

shh, fc83d08, sonic you, sonic-you (1), syu, vertebrate hedgehog homolog (1), vhh1 (1), wu:fc83d08 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and neurogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; digestive system; fin; head; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).

Genome Resources:

Alliance (1), Gene:30269 (1), Ensembl(GRCz11):ENSDARG00000068567 (1)

GENE EXPRESSION
All Expression Data:	448 figures from 337 publications
Wild-type Stages, Structures:	Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
	anal fin anterior neural keel ventral region anterior neural keel anterior neural rod axial chorda mesoderm axial mesoderm axis basal plate midbrain region blastema brain ventral region brain caudal fin lepidotrichium central nervous system ventral region central nervous system chordo neural hinge cloaca diencephalon anterior region diencephalon posterior region diencephalon ventral region diencephalon dorsal fin lepidotrichium endoderm epidermal basal stratum epidermis esophagus eye fin fin bud floor plate floor plate diencephalic region floor plate neural rod floor plate neural tube floor plate rhombomere region floor plate spinal cord region forebrain anterior region forebrain ventral region forebrain forebrain midbrain boundary forebrain neural keel forebrain neural rod gill gut endoderm gut endodermal cell gut epithelial cell gut gut endothelial cell gut epithelium head hindbrain floor plate hindbrain notochord hindbrain hindbrain neural plate hypoblast hypochord hypothalamus anterior region hypothalamus antero-dorsal region hypothalamus medial region hypothalamus posterior region hypothalamus intestinal bulb epithelium intestinal bulb primordium anterior-most region lateral floor plate mandibular arch skeleton medial floor plate mesenchyme pectoral fin mesoderm mesoderm pectoral fin bud mid diencephalic organizer central region mid diencephalic organizer dorsal region mid diencephalic organizer ventral region mid diencephalic organizer midbrain ventral region midbrain mouth ectoderm neural crest neural keel ventral region neural keel neural plate neural rod neural tube ventral region neurocranium neuroectoderm antero-ventral region neuroectoderm ventral region neuroectoderm notochord distal region notochord posterior side notochord notochord posterior region optic stalk optic tectum oral ectoderm oral epithelium oral region ectoderm oral region pectoral fin pectoral fin bud anterior margin pectoral fin bud posterior margin pectoral fin bud posterior region pectoral fin bud pectoral fin lepidotrichium pectoral fin musculature pelvic fin lepidotrichium pharyngeal arch endoderm pharyngeal arch 2 pharyngeal endoderm pharyngeal epithelium pharyngeal pouch 1 pharynx endoderm pharynx pneumatic duct postcranial axial cartilage prechordal plate preoptic area presumptive diencephalon presumptive dorsal mesoderm presumptive floor plate presumptive shield presumptive swim bladder pretectum proctodeum regenerating fin retina retinal ganglion cell serotonergic neuron shield somite spinal cord spinal cord neural keel spinal cord neural tube stomodeum swim bladder epithelium swim bladder swim bladder bud epithelium swim bladder bud tail bud tegmentum telencephalon thalamus third ventricle anatomical region unspecified whole organism zona limitans intrathalamica zone of polarizing activity pectoral fin bud
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
shha_unspecified	Unspecified	Unknown	Unknown
t4	Deficiency	Unknown	Unknown	SPONTANEOUS	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tbq70	Unknown	Unknown	Unknown	ENU
tbx392	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
tq252	Point Mutation	Unknown	Unknown		European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
vcc8Gt	Transgenic Insertion	Intron 1	Unknown	DNA_AND_TALEN

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-shha	N/A	19
MO2-shha	N/A	1
MO3-shha	N/A	1
MO4-shha	N/A	2
MO5-shha	N/A	1
MO6-shha	N/A	1
MO7-shha	N/A	1
TALEN1-shha	vcc8Gt	1
TALEN2-shha		1
TALEN3-shha		1

PHENOTYPE

Data:

31 figures from 20 publications

Observed in:

DISEASE ASSOCIATED WITH shha HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 3	Alliance	Holoprosencephaly 3	142945
solitary median maxillary central incisor	Alliance	Single median maxillary central incisor	147250
		Microphthalmia with coloboma 5	611638
		Schizencephaly	269160

DISEASE ASSOCIATED WITH shha VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	adenohypophysis development (more)
Cellular Component	membrane (more)
Molecular Function	hydrolase activity (more)

GO Terms (all 71)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	shha-201 (1)	4551	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES No data available

PLASMIDS

Addgene:ZE10 sonic hedgehog pT7TS

Addgene:ZE12 sonic hedgehog CMV

Addgene:shha-pCRII

CONSTRUCTS WITH SEQUENCES FROM shha

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(-2.4shha-A:GFP)	shha	GFP	Danio rerio	2	5
Tg(-2.4shha-AB:GFP)	shha	GFP	Danio rerio	1	3
Tg(-2.4shha-ABC:DsRed)	shha	DsRed	Danio rerio	1	3
Tg(-2.4shha-ABC:DsRed.T4)	shha	DsRed	Danio rerio	1	2
Tg(-2.4shha-ABC:GFP)	shha	GFP	Danio rerio	4	42
Tg(-2.4shha-AC:GFP)	shha	GFP	Danio rerio	1	3
Tg(-2.4shha-B:GFP)	shha	GFP	Danio rerio	2	5
Tg(-2.4shha-BC:GFP)	shha	GFP	Danio rerio	3	3
Tg(-2.4shha-C:GFP)	shha	GFP	Danio rerio	2	5
Tg(-2.4shha-E1:GFP)	shha, sox9a	GFP	Danio rerio	1	2
Tg(-2.4shha-M12:GFP)	shha	GFP	Danio rerio	1	2
Tg(-2.4shha-M13:GFP)	shha	GFP	Danio rerio	1	2
Tg(-2.4shha:GFP)	shha	GFP	Danio rerio	1	7
Tg(-2.7shha:GFP)	shha	GFP	Danio rerio	1	20
Tg(hsp70l:shha-EGFP)	hsp70l	EGFP, shha	Danio rerio	1	7
Tg(krt18a.1:shha-RFP)	krt18a.1	RFP, shha	Danio rerio	1	3
Tg(shha-gata2a:GAL4-VP16)	gata2a, shha	GAL4, VP16	Danio rerio	2	2
Tg(shha:ccbe1,TagRFP)	shha	ccbe1, TagRFP	Danio rerio	1	3
Tg(shha:GAL4FF)	shha	GAL4FF	Danio rerio	1	3
Tg(shha:h2az2a-EGFP)	shha	EGFP, h2az2a	Danio rerio	1	1
Tg(shha:vegfc,mTurquoise)	shha	mTurquoise, vegfc	Danio rerio	1	4
tg(tetre:shha-mcherry,myl7:egfp)	myl7, TETRE	EGFP, mCherry, shha	Danio rerio	0	1
Tg(UAS:EGFP,UAS:shha)	UAS	EGFP, shha	Danio rerio	1	4
Tg(UAS:shha)	UAS	shha	Danio rerio	1	3
Tg(UAS:shha,myl7:EGFP)	myl7	EGFP, shha	Danio rerio	2	3
Tg(UAS:shha-EGFP,Xla.Cry1:GFP)		EGFP, GFP, shha	Danio rerio, Xenopus laevis	1	2

MARKER RELATIONSHIPS

shha Contained in:	[BAC] CH211-105D1 (1), CH211-150E22 (1)
shha Encodes:	[EST] fc83d08 [cDNA] MGC:194075 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131063 (1)	2600 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU041319 (1)	174262 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0B5JF88 (1)	418 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 36)

ORTHOLOGY for shha ( Chr: 7 )

CITATIONS (825)

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