Gene

shha

ID
ZDB-GENE-980526-166
Name
sonic hedgehog signaling molecule a
Symbol
shha Nomenclature History
Previous Names
  • shh
  • fc83d08
  • sonic you
  • sonic-you (1)
  • syu
  • vertebrate hedgehog homolog (1)
  • vhh1 (1)
  • wu:fc83d08 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and neurogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; digestive system; fin; head; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).
Genome Resources
Note
None
Expression
All Expression Data
452 figures from 340 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
31 figures from 20 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With shha Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
holoprosencephaly 3 Alliance Holoprosencephaly 3 142945
solitary median maxillary central incisor Alliance Single median maxillary central incisor 147250
Microphthalmia with coloboma 5 611638
Schizencephaly 269160
Associated With shha Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000320 Hedgehog, N-terminal signalling domain
Domain IPR001767 Hedgehog protein, Hint domain
Domain IPR003586 Hint domain C-terminal
Domain IPR003587 Hint domain N-terminal
Family IPR001657 Hedgehog protein
Homologous_superfamily IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Homologous_superfamily IPR036844 Hint domain superfamily
PTM IPR006141 Intein N-terminal splicing region
Domain Details Per Protein
Protein Length Hedgehog, N-terminal signalling domain Hedgehog protein Hedgehog protein, Hint domain Hedgehog signalling/DD-peptidase zinc-binding domain superfamily Hint domain C-terminal Hint domain N-terminal Hint domain superfamily Intein N-terminal splicing region
UniProtKB:Q92008 418
UniProtKB:A0A0B5JF88 418
UniProtKB:Q1MTB5 418
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations