Gene

shha

ID

ZDB-GENE-980526-166

Name

sonic hedgehog signaling molecule a

Symbol

shha Nomenclature History

Previous Names

shh
fc83d08
sonic you
sonic-you (1)
syu
vertebrate hedgehog homolog (1)
vhh1 (1)
wu:fc83d08 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and neurogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; digestive system; fin; head; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

479 figures from 366 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 34 figures from 23 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shha Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Holoprosencephaly 3	142945
		Microphthalmia with coloboma 5	611638
		Schizencephaly	269160
		Single median maxillary central incisor	147250

Associated With shha Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000320	Hedgehog, N-terminal signalling domain
Domain	IPR001767	Hedgehog protein, Hint domain
Domain	IPR003586	Hint domain C-terminal
Domain	IPR003587	Hint domain N-terminal
Family	IPR001657	Hedgehog protein
Homologous_superfamily	IPR009045	Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Homologous_superfamily	IPR036844	Hint domain superfamily
PTM	IPR006141	Intein N-terminal splicing region