Gene

ddx3xb

ID
ZDB-GENE-980526-150
Name
DEAD-box helicase 3 X-linked b
Symbol
ddx3xb Nomenclature History
Previous Names
  • ddx3b
  • etID309900.24 (1)
  • p110a
  • pl10
  • pl10a
  • wu:fb43h11
  • wu:fy72b06
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable RNA binding activity and RNA helicase activity. Acts upstream of or within brain development. Predicted to be active in P granule and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to several human genes including DDX3X (DEAD-box helicase 3 X-linked).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Fitzgerald et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddx3xb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder, X-linked syndromic, Snijders Blok type 300958
Associated With ddx3xb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
Domain IPR001650 Helicase, C-terminal
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014014 RNA helicase, DEAD-box type, Q motif
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATP-dependent RNA helicase DEAD-box, conserved site DEAD/DEAH box helicase domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase RNA helicase, DEAD-box type, Q motif
UniProtKB:F1RCB2 688
UniProtKB:X1WHB2 228
UniProtKB:O42375 688
UniProtKB:Q6PBB2 688
UniProtKB:X1WFB0 296
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations