Gene

foxd3

ID
ZDB-GENE-980526-143
Name
forkhead box D3
Symbol
foxd3 Nomenclature History
Previous Names
  • fkd-6 (1)
  • fkd6 (1)
  • fkh6
  • forkhead-6
  • mother superior (2)
  • zgc:111934
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and response to thyroid hormone. Predicted to localize to nuclear chromatin. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3).
Genome Resources
Note
None
Expression
All Expression Data
181 figures from 133 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxd3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Autoimmune disease, susceptibility to, 1} 607836
Associated With foxd3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018122 Fork head domain conserved site1
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site1 Fork head domain conserved site 2 Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:O73782 371
UniProtKB:F1R5S7 371
UniProtKB:Q502Q4 371
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations