Gene

foxd3

ID

ZDB-GENE-980526-143

Name

forkhead box D3

Symbol

foxd3 Nomenclature History

Previous Names

fkd-6 (1)
fkd6 (1)
fkh6
forkhead-6
mother superior (2)
zgc:111934

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and response to thyroid hormone. Predicted to localize to nuclear chromatin. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3).

Genome Resources

Note

None

Expression

All Expression Data

181 figures from 133 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 20 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxd3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Autoimmune disease, susceptibility to, 1}	607836

Associated With foxd3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily