ZFIN Gene: foxd3

ZFIN ID: ZDB-GENE-980526-143

ZFIN ID: ZDB-GENE-980526-143

Gene Name:

forkhead box D3

Gene Symbol:

foxd3 Nomenclature History

Previous Names:

fkd-6 (1), fkd6 (1), fkh6, forkhead-6, mother superior (2), zgc:111934

Gene Type:

protein_coding_gene

Location:

Chr: 6 Mapping Details/Browsers

Description:

Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and neural crest cell migration. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3).

Genome Resources:

Alliance (1), Gene:30548 (1), Ensembl(GRCz11):ENSDARG00000021032 (1)

GENE EXPRESSION
All Expression Data:	181 figures from 133 publications
Wild-type Stages, Structures:	Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
	adaxial cell anatomical structure axial mesoderm brain cranial ganglion cranial neural crest cranial neural crest cell cranium glial cell endoderm epiphysis female organism floor plate glial cell glial cell (sensu Vertebrata) head glioblast hindbrain lateral region hindbrain hindbrain neural keel immature Schwann cell lateral line glial cell (sensu Vertebrata) lateral line lateral line primordium male organism margin dorsal side margin lateral region margin midbrain hindbrain boundary neural rod migratory neural crest cell myelinating Schwann cell neural crest glioblast (sensu Vertebrata) neural crest neural crest cell neural crest neural crest cell nucleus neural crest cell neural crest midbrain neural keel neural plate antero-lateral margin neural plate neural plate border neuroectoderm neural crest neuroectoderm notochord perineuronal satellite cell peripheral nervous system pharyngeal arch posterior lateral line ganglion glial cell posterior lateral line ganglion premigratory neural crest premigratory neural crest cell premigratory trunk neural crest presumptive enteric nervous system presumptive floor plate presumptive mesoderm shield somite spinal cord spinal cord neural keel tail bud trigeminal ganglion glial cell trigeminal ganglion glial cell (sensu Vertebrata) trunk glioblast trunk neural crest trunk neural crest cell unspecified whole organism anterior region whole organism dorsal region whole organism dorsal side whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ct110aGt	Transgenic Insertion	Unknown	Unknown	DNA
ct110aRGt	Transgenic Insertion	Unknown	Unknown	DNA
m188	Unknown	Unknown	Unknown	ENU
sa174	Point Mutation	Unknown	Unknown	ENU
sa20726	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
zdf10	Small Deletion	Unknown	Frameshift, Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-foxd3		1
MO1-foxd3	N/A	10
MO2-foxd3	N/A	7
MO3-foxd3	N/A	8
MO4-foxd3	N/A	1

PHENOTYPE

Data:

19 figures from 11 publications

Observed in:

DISEASE ASSOCIATED WITH foxd3 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Autoimmune disease, susceptibility to, 1}	607836

DISEASE ASSOCIATED WITH foxd3 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	negative regulation of transcription, DNA-templated (more)
Cellular Component	nucleus (more)
Molecular Function	DNA-binding transcription factor activity (more)

GO Terms (all 24)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	foxd3-201 (1)	1799	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM foxd3

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(foxd3:EGFP)	foxd3	EGFP	Danio rerio	1	4
Tg(foxd3:GFP)	foxd3	GFP	Danio rerio	3	76
tgbac(foxd3:avi-2a-citrine)	foxd3	2A, AVI, Citrine	Danio rerio	1	1
tgbac(foxd3:egfp)	foxd3	EGFP	Danio rerio	1	1

MARKER RELATIONSHIPS

foxd3 Contained in:	[BAC] DKEY-148H10 (1) (order this)
foxd3 Encodes:	[cDNA] MGC:111934 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131290 (1)	1782 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX664614 (1)	184225 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1R5S7 (1)	371 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 14)

ORTHOLOGY for foxd3 ( Chr: 6 )

CITATIONS (260)

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