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ZIRC
ZFIN ID: ZDB-GENE-980526-143
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Gene Name: forkhead box D3
Gene Symbol: foxd3    Nomenclature History

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Previous Names: fkd-6 (1), fkd6 (1), fkh6, forkhead-6, mother superior (2), zgc:111934

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and neural crest cell migration. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in vitiligo. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Orthologous to human FOXD3 (forkhead box D3).
Genome Resources: Alliance (1),  Gene:30548 (1),  Ensembl(GRCz11):ENSDARG00000021032 (1)
GENE EXPRESSION
All Expression Data: 180 figures from 132 publications
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct110aGt Transgenic Insertion Unknown Unknown DNA
ct110aRGt Transgenic Insertion Unknown Unknown DNA
m188 Unknown Unknown Unknown ENU
sa174 Point Mutation Unknown Unknown ENU
sa20726 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • zdf10 Small Deletion Unknown Frameshift, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-foxd3 N/A 10
    MO2-foxd3 N/A 7
    MO3-foxd3 N/A 8
    MO4-foxd3 N/A 1
    PHENOTYPE
    Data: 19 figures from 11 publications
    Observed in:
    DISEASE ASSOCIATED WITH foxd3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Autoimmune disease, susceptibility to, 1} 607836
    DISEASE ASSOCIATED WITH foxd3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001766 (1)
  • InterPro:IPR018122 (1)
  • InterPro:IPR030456 (1)
  • InterPro:IPR036388 (1)
  • InterPro:IPR036390 (1)
  • PROSITE:PS00657 (1)
  • PROSITE:PS00658 (1)
  • PROSITE:PS50039 (1)
  • Pfam:PF00250 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxd3-201 (1)    Ensembl 1799
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxd3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(foxd3:EGFP) foxd3 EGFP Danio rerio 1 4
    Tg(foxd3:GFP) foxd3 GFP Danio rerio 3 75
    tgbac(foxd3:avi-2a-citrine) foxd3 2A,  AVI,  Citrine Danio rerio 1 1
    tgbac(foxd3:egfp) foxd3 EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    foxd3 Contained in: [BAC] DKEY-148H10 (1) (order this)
    foxd3 Encodes: [cDNA] MGC:111934 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131290 (1) 1782 bp
    Select Tool
    Genomic GenBank:BX664614 (1) 184225 bp
    Select Tool
    Polypeptide UniProtKB:F1R5S7 (1) 371 aa
    Select Tool
    Sequence Clusters UniGene:75816 (1)
    Sequence Information (all 15)
    ORTHOLOGY for foxd3 ( Chr: 6 )
    CITATIONS (252)