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General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-137
Gene Name: cholinergic receptor, nicotinic, alpha 1 (muscle)
Gene Symbol: chrna1
Sequence Ontology ID : SO:0001217

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Previous Names: AChR alpha 1 (1), nic-1 (1), nic1, nic, nicotinic receptor, zgc:86593

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits cation channel activity. Contributes to acetylcholine binding activity and acetylcholine receptor activity. Involved in several processes, including chemical synaptic transmission;  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b107 Small Deletion Intron 6 Unknown G_RAYS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • b817 Unknown Unknown Unknown ENU
    dtbn12 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tk48d Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH chrna1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital myasthenic syndrome 1A Myasthenic syndrome, congenital, 1A, slow-channel 601462
    congenital myasthenic syndrome 1B Myasthenic syndrome, congenital, 1B, fast-channel 608930
    multiple pterygium syndrome Multiple pterygium syndrome, lethal type 253290
    DISEASE ASSOCIATED WITH chrna1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    congenital myasthenic syndrome chrna1dtbn12/dtbn12 standard conditions Walogorsky et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromuscular synaptic transmission (more)
    Cellular Component acetylcholine-gated channel complex (more)
    Molecular Function CONTRIBUTES_TO   acetylcholine receptor activity (more)
    GO Terms (all 32)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA chrna1-002 (1) 799
    mRNA chrna1-201 (1) 2187
    chrna1-202 (1) 560
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrna1 No data available
    MARKER RELATIONSHIPS
    chrna1 Contained in: [BAC] DKEY-91G17 (1) (order this)
    chrna1 Contains: [SNP] rs3727947 (1)
    chrna1 Encodes: [cDNA] MGC:86593 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131445 (1) 2218 bp
    Genomic GenBank:CT573297 (1) 61348 bp
    Select Tool
    Polypeptide UniProtKB:Q98880 (1) 456 aa
    Sequence Clusters UniGene:75091 (1)
    Sequence Information (all 18)
    ORTHOLOGY for chrna1 ( Chr: 6 )
    CITATIONS (87)