ZFIN ID: ZDB-GENE-980526-123
Gene Name: Janus kinase 2b
Gene Symbol: jak2b    Nomenclature History

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Previous Name: Jak2b kinase

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; histone binding activity; and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in erythrocyte differentiation. Predicted to localize to cytoskeleton and membrane. Is expressed in several structures, including lateral line; lens; mandibular arch skeleton; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including familial erythrocytosis 1; hematologic cancer (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and thrombocytosis. Orthologous to human JAK2 (Janus kinase 2).
Genome Resources: Alliance (1),  Gene:30298 (1),  Ensembl(GRCz11):ENSDARG00000018882 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH jak2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
Budd-Chiari syndrome Alliance {Budd-Chiari syndrome, somatic} 600880
essential thrombocythemia Alliance Thrombocythemia 3 614521
familial erythrocytosis 1 Alliance Erythrocytosis, somatic 133100
myelofibrosis Alliance Myelofibrosis, somatic 254450
polycythemia vera Alliance Polycythemia vera, somatic 263300
DISEASE ASSOCIATED WITH jak2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chromatin organization (more)
Cellular Component cytoskeleton (more)
Molecular Function ATP binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA jak2b-203 (1)    Ensembl 3389
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM jak2b No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131087 (1) 4536 nt
Genomic GenBank:CABZ01049033 (1) 19564 nt
Polypeptide UniProtKB:C0RW38 (1) 1126 aa
Sequence Information (all 18)
ORTHOLOGY for jak2b ( Chr: 5 )
CITATIONS (34)