Gene

tncb

ID

ZDB-GENE-980526-104

Name

tenascin Cb

Symbol

tncb Nomenclature History

Previous Names

tenc
tnc
etID309720.5 (1)
wu:fk04d02

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Acts upstream of or within several processes, including axon development; positive regulation of synaptic assembly at neuromuscular junction; and regulation of neuron projection development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schweitzer et al., 2005
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tncb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 56	Alliance	Deafness, autosomal dominant 56	615629

Associated With tncb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR003961	Fibronectin type III
Domain	IPR041161	Tenascin, EGF-like domain
Family	IPR033078	Tenascin-C
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	EGF-like domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen-like, C-terminal	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	Tenascin-C	Tenascin, EGF-like domain
UniProtKB:A2BDW3 InterPro	612
UniProtKB:A0A2R8PV67 InterPro	1719
UniProtKB:Q90484 InterPro	614
UniProtKB:Q4FAI8 InterPro	1710
UniProtKB:E9QHI1 InterPro	1720
UniProtKB:A2BDW2 InterPro	1662
UniProtKB:B3DJP3 InterPro	1811
UniProtKB:F1QYE2 InterPro	1811
UniProtKB:A0A2R8S019 InterPro	1685

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tnc-202 (1) Ensembl	6899 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnc-205 (1) Ensembl	5384 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tnc-003 (1) Ensembl	524 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tnc-004 (1) Ensembl	763 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tnc-005 (1) Ensembl	749 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations