ZFIN Gene: tnc

ZFIN ID: ZDB-GENE-980526-104

ZFIN ID: ZDB-GENE-980526-104

Gene Name:

tenascin C

Gene Symbol:

tnc

Sequence Ontology ID :

SO:0001217

Previous Names:

etID309720.5 (1), tenc, wu:fk04d02

Location:

Chr: 5 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Involved in several processes, including generation of neurons; neural crest cell migration; and positive regulation of synaptic growth at neuromuscular junction. Predicted to localize to the ...

GENE EXPRESSION
All Expression Data:	13 figures from 6 publications
Wild-type Stages, Structures:	Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
	adaxial cell brain grey matter horizontal myoseptum hypochord neural crest cell notochord pharyngeal arch somite spinal cord motor neuron unspecified vertical myoseptum whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu3513	Point Mutation	Unknown	Premature Stop	ENU
hu3580	Point Mutation	Unknown	Premature Stop	ENU
hu3583	Point Mutation	Unknown	Premature Stop	ENU
sa1576	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa8813	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20437	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20438	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33617	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33618	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40443	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	Fig. 7 from Schweitzer et al., 2005
Observed in:	axon extension motor neuron axon

DISEASE ASSOCIATED WITH tnc HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 56	Deafness, autosomal dominant 56	615629

DISEASE ASSOCIATED WITH tnc VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	axonal fasciculation (more)
Cellular Component	collagen-containing extracellular matrix (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000742 (1) InterPro:IPR002181 (1) InterPro:IPR003961 (1) InterPro:IPR013032 (1) InterPro:IPR013783 (1) InterPro:IPR033078 (1) InterPro:IPR036056 (1) InterPro:IPR036116 (1) InterPro:IPR041161 (1)	PROSITE:PS00022 (1) PROSITE:PS01186 (1) PROSITE:PS50026 (1) PROSITE:PS50853 (1) PROSITE:PS51406 (1)	Pfam:PF00041 (1) Pfam:PF00147 (1) Pfam:PF18720 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	tnc-003 (1)	524	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tnc-004 (1)	763	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tnc-005 (1)	749	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnc-202 (1)	6899	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tnc-205 (1)	5384	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
mRNA	ottdart00000019924 (1)	6633	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ottdart00000019925 (1)	1896	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tnc No data available

MARKER RELATIONSHIPS

tnc Contained in:	[BAC] CH73-195I19 (1) (order this), CH211-166O17 (1) (order this)
tnc Encodes:	[EST] fk04d02 (1) [cDNA] MGC:195114 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_130907 (1)	5746 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CT737232 (1)	147186 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:B3DJP3 (1)	1811 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:33789 (1)

Sequence Information (all 40)

OTHER tnc GENE PAGES

Alliance (1)

Gene:30037 (1)

VEGA:OTTDARG00000032698 (1)

Ensembl(GRCz11):ENSDARG00000021948 (1)

ORTHOLOGY for tnc ( Chr: 5 )

CITATIONS (51)

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