Gene
tnc
- ID
- ZDB-GENE-980526-104
- Name
- tenascin C
- Symbol
- tnc Nomenclature History
- Previous Names
-
- etID309720.5 (1)
- tenc
- wu:fk04d02
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in several processes, including generation of neurons; neural crest cell migration; and positive regulation of synaptic growth at neuromuscular junction. Predicted to localize to collagen-containing extracellular matrix. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).
- Genome Resources
- Note
- None
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schweitzer et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 56 | Alliance | Deafness, autosomal dominant 56 | 615629 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR041161 | Tenascin, EGF-like domain |
| Family | IPR033078 | Tenascin-C |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen-like, C-terminal | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Tenascin-C | Tenascin, EGF-like domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8PV67
|
1719 | ||||||||
|
UniProtKB:B3DJP3
|
1811 | ||||||||
|
UniProtKB:Q4FAI8
|
1710 | ||||||||
|
UniProtKB:E9QHI1
|
1720 | ||||||||
|
UniProtKB:F1QYE2
|
1811 | ||||||||
|
UniProtKB:Q90484
|
614 | ||||||||
|
UniProtKB:A2BDW2
|
1662 | ||||||||
|
UniProtKB:A2BDW3
|
612 | ||||||||
|
UniProtKB:A0A2R8S019
|
1685 |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl