Gene

tnc

ID
ZDB-GENE-980526-104
Name
tenascin C
Symbol
tnc Nomenclature History
Previous Names
  • etID309720.5 (1)
  • tenc
  • wu:fk04d02
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Involved in several processes, including generation of neurons; neural crest cell migration; and positive regulation of cellular component organization. Predicted to localize to collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Schweitzer et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 56 Alliance Deafness, autosomal dominant 56 615629
Associated With tnc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain IPR003961 Fibronectin type III
Domain IPR041161 Tenascin, EGF-like domain
Family IPR033078 Tenascin-C
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036056 Fibrinogen-like, C-terminal
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length EGF-like domain Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain Fibrinogen-like, C-terminal Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Tenascin-C Tenascin, EGF-like domain
UniProtKB:A0A2R8PV67 1719
UniProtKB:A0A2R8S019 1685
UniProtKB:B3DJP3 1811
UniProtKB:F1QYE2 1811
UniProtKB:E9QHI1 1720
UniProtKB:Q90484 614
UniProtKB:Q4FAI8 1710
UniProtKB:A2BDW3 612
UniProtKB:A2BDW2 1662
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations