Gene
tncb
- ID
- ZDB-GENE-980526-104
- Name
- tenascin Cb
- Symbol
- tncb Nomenclature History
- Previous Names
-
- tenc
- tnc
- etID309720.5 (1)
- wu:fk04d02
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including axon development; positive regulation of synaptic assembly at neuromuscular junction; and regulation of neuron projection development. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; hypochord; myoseptum; and neural crest cell. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schweitzer et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 56 | Alliance | Deafness, autosomal dominant 56 | 615629 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000742 | EGF-like domain |
Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR041161 | Tenascin, EGF-like domain |
Family | IPR033078 | Tenascin-C |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
Protein | Length | EGF-like domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen-like, C-terminal | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Tenascin-C | Tenascin, EGF-like domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A2BDW3
|
612 | |||||||||
UniProtKB:A0A2R8PV67
|
1719 | |||||||||
UniProtKB:Q90484
|
614 | |||||||||
UniProtKB:Q4FAI8
|
1710 | |||||||||
UniProtKB:E9QHI1
|
1720 | |||||||||
UniProtKB:A2BDW2
|
1662 | |||||||||
UniProtKB:B3DJP3
|
1811 | |||||||||
UniProtKB:F1QYE2
|
1811 | |||||||||
UniProtKB:A0A2R8S019
|
1685 |
Interactions and Pathways
No data available
Plasmids
No data available