Gene
ccr2
- ID
- ZDB-GENE-151216-1
- Name
- chemokine (C-C motif) receptor 2
- Symbol
- ccr2 Nomenclature History
- Previous Names
-
- ccr5 (1)
- si:ch211-207g17.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have chemokine receptor activity. Involved in monocyte activation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and rheumatoid arthritis (multiple). Orthologous to several human genes including CCR2 (C-C motif chemokine receptor 2); CCR4 (C-C motif chemokine receptor 4); and CCR5 (C-C motif chemokine receptor 5 (gene/pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 12 | Alliance | {Macular degeneration, age-related, 12} | 613784 |
| coronary artery disease | Alliance | {Coronary artery disease, resistance to} | 607339 |
| type 1 diabetes mellitus 22 | Alliance | {Diabetes mellitus, insulin-dependent, 22} | 612522 |
| Polycystic lung disease | 219600 | ||
| {Hepatitis C virus, resistance to} | 609532 | ||
| {HIV infection, susceptibility/resistance to} | 609423 | ||
| {Rapid progression to AIDS from HIV1 infection} | 609423 | ||
| {West nile virus, susceptibility to} | 610379 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:A0A140LFQ7
|
354 | |||
|
UniProtKB:F1QYD4
|
358 |
Interactions and Pathways
No data available
Plasmids
No data available